PPM1B and ECHS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PPM1B	ECHS1
Description		protein phosphatase, Mg2+/Mn2+ dependent 1B	enoyl-CoA hydratase, short chain 1
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytosol Membrane	Mitochondrion Mitochondrial Matrix
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding	Enoyl-CoA Hydratase Activity Protein Binding
	Biological Process	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling	Fatty Acid Beta-oxidation
Pathways		ISG15 antiviral mechanism	Branched-chain amino acid catabolism Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA Beta oxidation of butanoyl-CoA to acetyl-CoA
Drugs			Hexanoyl-CoA Octanoyl-Coenzyme A Acetoacetyl-CoA 4-(N,N-Dimethylamino)Cinnamoyl-Coa
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258)	Lifespan ( 25918517) Nonunion in individuals with fractures ( 30680360)
Interacting Genes		19 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAP3K7 MSN PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2	10 interacting genes: CAPN1 CBWD2 CLDN12 CYP2E1 GRB2 LRRK1 LRRK2 PPM1B SERPINA1 UBA1
Entrez ID		5495	1892
HPRD ID		04796	03799
Ensembl ID		ENSG00000138032	ENSG00000127884
Uniprot IDs		O75688	P30084
PDB IDs		2P8E	2HW5
Enriched GO Terms of Interacting Partners?
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