CASZ1 and PALB2

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		CASZ1	PALB2
Description		castor zinc finger 1	partner and localizer of BRCA2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Intracellular Membrane-bounded Organelle	Nucleoplasm
	Molecular Function	DNA Binding Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development
Pathways			HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange
Drugs
Diseases			Fanconi anemia
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Atrial fibrillation ( 30061737 29892015) Beard thickness ( 26926045) Blood pressure ( 21572416) Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Diastolic blood pressure ( 27841878 29403010 28739976 27618447 27618452 25249183 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Estimated glomerular filtration rate ( 31152163 31015462) Facial morphology ( 31763980) Hypertension ( 25249183 30487518) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Male-pattern baldness ( 28196072) Mean arterial pressure ( 29403010 27618448 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Microalbuminuria ( 31511532) Pulse pressure ( 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Resistance to antihypertensive treatment in hypertension ( 31545351) Resistant hypertension ( 31545351) Stroke ( 29531354) Systolic blood pressure ( 19430479 27841878 29403010 28739976 27618452 25249183 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urinary albumin-to-creatinine ratio ( 26631737 31511532)	Bipolar disorder ( 17554300)
Interacting Genes		9 interacting genes: APP BAG4 BCAR3 ESR2 PALB2 PPM1D PTPN1 RAF1 WT1	28 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3
Entrez ID		54897	79728
HPRD ID		07897	07966
Ensembl ID		ENSG00000130940	ENSG00000083093
Uniprot IDs		B3KRV8 Q86V15	H3BN63 Q86YC2
PDB IDs			2W18 3EU7
Enriched GO Terms of Interacting Partners?
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