PALB2 and SNAI1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		PALB2	SNAI1
Description		partner and localizer of BRCA2	snail family transcriptional repressor 1
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GO Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Kinase Binding Metal Ion Binding E-box Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Somitogenesis Inner Cell Mass Cell Proliferation Mesoderm Development Animal Organ Morphogenesis Multicellular Organism Growth Post-anal Tail Morphogenesis Negative Regulation Of Apoptotic Process Embryonic Organ Development	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Roof Of Mouth Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange	Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases		Fanconi anemia
GWAS		Bipolar disorder ( 17554300)	Psoriasis ( 20953189)
Interacting Genes		28 interacting genes: BCAS3 BRCA2 CASZ1 CCL5 CST6 DIRAS3 ERRFI1 GREB1 HNRNPC IL13RA2 IL24 KLK6 LRATD2 LYPD3 MRC2 NAT2 PDS5B PRDM14 RAD51 RAD51AP1 RAD51C RHOBTB2 RNF168 SERPINB5 SNAI1 THRSP USP2 XRCC3	33 interacting genes: ACTN2 BRMS1 CTDSP1 CTDSP2 CTDSPL EP300 FBXL14 FBXO22 GSK3B HOXD4 KRT31 KRT40 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PPIL2 PTEN PTPN1 RCOR1 TGFB1 TNFAIP3 TRIM23 USP17L2 XRCC3
Entrez ID		79728	6615
HPRD ID		07966	05025
Ensembl ID		ENSG00000083093	ENSG00000124216
Uniprot IDs		H3BN63 Q86YC2	O95863
PDB IDs		2W18 3EU7	2Y48 3W5K 3ZMT 4QLI
Enriched GO Terms of Interacting Partners?
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