PLAGL1 and PIAS2

Number of citations of the paper that reports this interaction (PubMedID 15208321)
11

Data Source:
BioGRID (pull down)

		PLAGL1	PIAS2
Description		PLAG1 like zinc finger 1	protein inhibitor of activated STAT 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Nuclear Body Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm PML Body Nuclear Speck
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Metal Ion Binding	RNA Polymerase II Transcription Factor Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Androgen Receptor Binding SUMO Ligase Activity
	Biological Process	Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription By RNA Polymerase II Protein Sumoylation Androgen Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Androgen Receptor Signaling Pathway
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases		Transient neonatal diabetes mellitus (TNDM)
GWAS		Anti-saccade response ( 29064472) Eosinophil percentage of granulocytes ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Peanut allergy (maternal genetic effects) ( 29489655) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		10 interacting genes: CREBBP DAXX EP300 KAT2B PIAS2 PML SMAD3 SUMO1 TP53 UBE2I	72 interacting genes: ACY3 ADA AKT1 AR C1QA CCHCR1 CCNDBP1 CDCA8 CHMP4B CLDN2 CREBBP CTBP1 DDX39B DNMT3A ELK1 ESR1 ESR2 FLI1 GFAP GLUL GOLGA2 GRM8 GTF2I GTF2IRD1 HDAC3 HUWE1 JUN LMNA LMNB1 MAPK8 MAPKAPK2 MBD1 MITF MSX2 MX2 NAV2 NR3C1 PARK7 PAXIP1 PGR PHC1 PIAS1 PIAS4 PLAG1 PLAGL1 PML PRKAB2 RUFY1 SIAH1 SIAH2 SMAD3 SMAD4 SNAI2 SNIP1 SREBF2 STAT4 SUMO1 SUMO1P1 SUMO2 SUMO3 TICAM2 TP53 TRIM23 TRIM27 TRIM55 TRIM63 TSR2 UBE2I UBE2L3 ZBED1 ZBTB8A ZNF451
Entrez ID		5325	9063
HPRD ID		16010	06944
Ensembl ID		ENSG00000118495	ENSG00000078043
Uniprot IDs		A1YLA1 A1YLA2 Q9UM63	A0A024RC49 O75928 Q2TA77
PDB IDs			2ASQ 4FO9
Enriched GO Terms of Interacting Partners?
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