PKNOX1 and RFX3

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		PKNOX1	RFX3
Description		PBX/knotted 1 homeobox 1	regulatory factor X3
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Transcription Factor Complex Cytoplasm	Nuclear Chromatin Extracellular Region Nucleus Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Angiogenesis Transcription By RNA Polymerase II T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Endocrine Pancreas Development Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of Insulin Secretion Cilium Assembly Cilium-dependent Cell Motility Epithelial Cilium Movement Involved In Determination Of Left/right Asymmetry Type B Pancreatic Cell Maturation Positive Regulation Of Type B Pancreatic Cell Development
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)	Bisphosphonate-associated atypical femoral fracture ( 31006051) Body mass index ( 28552196) Gout ( 25967671) Insomnia ( 29520036) Major depressive disorder ( 27479909) Monobrow thickness ( 26926045) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure in sickle cell anemia ( 24058526) Weight ( 28552196)
Interacting Genes		16 interacting genes: APP HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 MEIS1 PAX6 PBX1 PBX2 PCNT POU2F1 RFX3 TLX1 VPS37C ZBTB3	12 interacting genes: BIN1 CREB1 EWSR1 FHL2 FHL3 IRF6 PKNOX1 RFX1 RFX4 RFX6 TRAF2 TRIP6
Entrez ID		5316	5991
HPRD ID		03653	03215
Ensembl ID		ENSG00000160199	ENSG00000080298
Uniprot IDs		B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87	P48380
PDB IDs		1X2N
Enriched GO Terms of Interacting Partners?
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