PIK3CB and HPS6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PIK3CB	HPS6
Description		phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex Membrane Midbody Intracellular Membrane-bounded Organelle	Lysosomal Membrane Endoplasmic Reticulum Membrane BLOC-2 Complex Early Endosome Membrane
	Molecular Function	Protein Binding ATP Binding Kinase Activity 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Phosphatidylinositol Kinase Activity Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity	Protein Binding Rab GTPase Binding GTP-dependent Protein Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Cell-matrix Adhesion Phosphatidylinositol Biosynthetic Process Endocytosis Autophagy Chemotaxis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Axon Guidance Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Phosphorylation Cell Migration Cytokine-mediated Signaling Pathway Platelet Activation Positive Regulation Of Neutrophil Apoptotic Process Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Positive Regulation Of Protein Kinase B Signaling Platelet Aggregation Regulation Of Clathrin-dependent Endocytosis	Organelle Organization Blood Coagulation Melanocyte Differentiation Lysosome Localization Protein Localization To Membrane
Pathways		PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Nephrin family interactions VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants
Drugs		Caffeine XL765
Diseases			Hermansky-Pudlak syndrome (HPS)
GWAS		Male-pattern baldness ( 28196072)	Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435)
Interacting Genes		11 interacting genes: AGTR2 ALAS1 DVL3 HCK HPS6 MME PIK3R1 PRKCD PRKCE RAB5B YWHAQ	9 interacting genes: CREB1 EP300 HPS5 MARK4 MNAT1 OSGEP PIK3CB PUM3 TTC19
Entrez ID		5291	79803
HPRD ID		04234	08471
Ensembl ID		ENSG00000051382	ENSG00000166189
Uniprot IDs		B4DER4 B4DZI3 P42338	Q86YV9
PDB IDs
Enriched GO Terms of Interacting Partners?
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