PHF1 and TFCP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		PHF1	TFCP2
Description		PHD finger protein 1	transcription factor CP2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome ESC/E(Z) Complex Site Of Double-strand Break	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Protein-containing Complex
	Molecular Function	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Methylated Histone Binding Metal Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation	Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PRC2 methylates histones and DNA
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		24 interacting genes: ATXN7L1 BIRC7 BRD2 CALCOCO2 EZH2 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HSD17B14 NAB2 NEK6 PDLIM7 RBPMS TFCP2 THAP1 TRIM23 VAC14	70 interacting genes: ADPRH APBB1 ASAP3 BAG6 C19orf73 CA1 CAPN3 CASP8 CBX8 CDC73 COIL DNAJC27 DNAJC5B DPH1 E2F8 EAF1 EIF5B EPHA10 FAM120C FANCL FARS2 FBXL18 GPANK1 HDAC1 HDAC2 IRAK1BP1 LDB3 LSM1 MAPK1 MAPK14 MAPK8 MOB3C MORF4L1 MRPL11 MRPL40 MVP NABP1 NEDD9 NFE4 NOM1 NPEPL1 PHF1 PHF21B PIMREG PITPNM1 PLCB1 POLL POLR3GL PPIG PPP1R1B PPP3R2 PSMD5 RBMS1 RNF2 RXRB SDCBP SHTN1 SIN3A STMN2 SUMO1 TCEA2 TDRD1 TRAPPC12 TSPAN12 UBE2I UBP1 YJU2 YY1 ZCCHC10 ZCCHC12
Entrez ID		5252	7024
HPRD ID		04195	01790
Ensembl ID		ENSG00000112511	ENSG00000135457
Uniprot IDs		A0A140VJR4 A0A1U9X8A3 O43189	A0A024R120 Q12800
PDB IDs		2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP
Enriched GO Terms of Interacting Partners?
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