PHF1 and HSD17B14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PHF1	HSD17B14
Description		PHD finger protein 1	hydroxysteroid 17-beta dehydrogenase 14
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome ESC/E(Z) Complex Site Of Double-strand Break	Cytosol
	Molecular Function	DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Methylated Histone Binding Metal Ion Binding	Estradiol 17-beta-dehydrogenase Activity Protein Binding Identical Protein Binding Testosterone 17-beta-dehydrogenase (NADP+) Activity
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K27 Methylation Positive Regulation Of Histone H3-K27 Methylation	Estrogen Biosynthetic Process Steroid Catabolic Process Oxidation-reduction Process
Pathways		PRC2 methylates histones and DNA	Estrogen biosynthesis
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 26426971) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)	Blood protein levels ( 30072576) Resting metabolic rate ( 28476931)
Interacting Genes		24 interacting genes: ATXN7L1 BIRC7 BRD2 CALCOCO2 EZH2 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C6 H3C7 H3C8 H4C1 HSD17B14 NAB2 NEK6 PDLIM7 RBPMS TFCP2 THAP1 TRIM23 VAC14	16 interacting genes: CA8 CDKN2D CYTOR DDIT3 MIA3 MIR4435-2HG MPG NEK6 NTAQ1 NUDT18 PHF1 PSMA1 SNAPC3 SNRPC SREK1IP1 TBC1D22B
Entrez ID		5252	51171
HPRD ID		04195	16801
Ensembl ID		ENSG00000112511	ENSG00000087076
Uniprot IDs		A0A140VJR4 A0A1U9X8A3 O43189	A0A140VJH8 Q9BPX1
PDB IDs		2E5P 2M0O 4HCZ 5XFN 5XFO 5XFP	1YDE 5EN4 5HS6 5ICM 5ICS 5JS6 5JSF 5L7T 5L7W 5L7Y 5O42 5O43 5O6O 5O6X 5O6Z 5O72 5O7C 6EMM 6FFB 6G4L 6GBT 6GTB 6GTU 6H0M 6HNO
Enriched GO Terms of Interacting Partners?
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