SUFU and HMGA1

Number of citations of the paper that reports this interaction (PubMedID 14611647)
39

Data Source:
HPRD (two hybrid)

		SUFU	HMGA1
Description		SUFU negative regulator of hedgehog signaling	high mobility group AT-hook 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ciliary Tip Ciliary Base	Nucleus Nucleoplasm Transcription Factor Complex Cytosol Focal Adhesion Senescence-associated Heterochromatin Focus RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding AT DNA Binding Chromatin Binding Transcription Coactivator Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Transcription Factor Binding Enzyme Binding Nuclear Receptor Transcription Coactivator Activity Structural Constituent Of Chromatin Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Neural Tube Closure Heart Looping Ventricular Septum Development Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organism Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Aorta Development Negative Regulation Of Protein Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	DNA Unwinding Involved In DNA Replication Base-excision Repair Nucleosome Disassembly Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Proliferation Response To Virus Negative Regulation Of Chromatin Silencing Senescence-associated Heterochromatin Focus Assembly Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Nuclear Transport Protein-containing Complex Assembly Establishment Of Integrated Proviral Latency Oncogene-induced Cell Senescence Positive Regulation Of Cellular Senescence
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state	Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome
GWAS		Allergy ( 27182965) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Height ( 28552196) Nickel levels ( 26025379) Optic disc size ( 31809533) Prostate cancer ( 23535732) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 29403010)	Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Birth weight ( 31043758 27680694) Body mass index ( 26426971 28892062 20935630) Estimated glomerular filtration rate ( 31152163) FEV1 ( 30804560) Hand grip strength ( 29691431) Height ( 21998595 20881960 25282103 25429064 19396169 19343178 19893584 23563607 31562340 18391951 20397748 20189936) Hip circumference adjusted for BMI ( 25673412) Lung function (FVC) ( 30804560) Metabolic syndrome ( 31589552) Offspring birth weight ( 31043758) Regular attendance at a gym or sports club ( 29970889) Systolic blood pressure ( 30578418) Tonsillectomy ( 27182965 28928442) Type 2 diabetes (adjusted for BMI) ( 30297969) Uterine fibroids ( 31649266) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28552196 25673412 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412)
Interacting Genes		27 interacting genes: BTRC FBXL17 GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 ITCH LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF764	64 interacting genes: ANXA1 ANXA2 APEX1 APP ATF2 CDK1 CEBPB CREBBP CSNK2A1 CSNK2A2 CWC27 DNAJC8 EIF2S2 ELF1 EWSR1 GTF2F2 HEMGN HIPK2 HMGB1 HMGB2 HMGB3 HNRNPA1 HNRNPAB HNRNPD HNRNPDL HNRNPL HPF1 HSPA1A IRF1 JUN KAT2B METAP2 NCL NFKB1 NFYA NPM1 OLA1 ORC6 PA2G4 PARP1 PCBP1 PCBP2 POU2F1 POU2F2 POU3F1 PPARG PPP1R8 PRKCA PRMT6 PSIP1 PTBP1 RARA RARG RCC1 RN7SK RNF4 RXRA SP1 SRF SRPK2 SSB SUFU SYNCRIP UPF2
Entrez ID		51684	3159
HPRD ID		06124	02829
Ensembl ID		ENSG00000107882	ENSG00000137309
Uniprot IDs		A0A223LX15 Q9UMX1	P17096 Q5T6U8
PDB IDs		1M1L 4BL8 4BL9 4BLA 4BLB 4BLD 4KM8 4KM9 4KMD 4KMH	2EZD 2EZE 2EZF 2EZG
Enriched GO Terms of Interacting Partners?
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