SUFU and GLIS3

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		SUFU	GLIS3
Description		SUFU negative regulator of hedgehog signaling	GLIS family zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Ciliary Tip Ciliary Base	Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Neural Tube Closure Heart Looping Ventricular Septum Development Regulation Of Transcription, DNA-templated Proteolysis Signal Transduction Multicellular Organism Development Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Aorta Development Negative Regulation Of Protein Import Into Nucleus Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA-binding Transcription Factor Activity Skin Development Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Coronary Vasculature Development Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state
Drugs
Diseases		Basal cell nevus syndrome; Nevoid basal cell carcinoma syndrome; Gorlin syndrome	Permanent neonatal diabetes mellitus (PNDM)
GWAS		Allergy ( 27182965) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate ( 29403010) Height ( 28552196) Nickel levels ( 26025379) Optic disc size ( 31809533) Prostate cancer ( 23535732) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for body mass index ( 25673412) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White blood cell count ( 29403010)	Alzheimer's disease biomarkers ( 23562540) Blood sugar levels ( 29403010) Central corneal thickness ( 29760442) Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Chin dimples ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting plasma glucose ( 25187374) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Glaucoma (primary angle closure) ( 27064256) Height ( 28552196) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Homeostasis model assessment of beta-cell function ( 20081858) Intraocular pressure ( 29617998 29785010 30054594 30591961 29235454) Low high density lipoprotein cholesterol levels ( 26879886) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Medication use (adrenergics, inhalants) ( 31015401) Metabolite levels ( 23823483) Methotrexate phramacokinetics (acute lymphoblastic leukemia) ( 19901119) Neurociticism ( 29500382) Nicotine dependence ( 28440896) Offspring birth weight ( 31043758) Osteoarthritis of the hip or knee ( 29436472) Osteoarthritis of the hip or knee (with total joint replacement) ( 29436472) Peak expiratory flow ( 30804560) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Red blood cell count ( 27863252) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482) Spontaneous preterm birth (preterm delivery) ( 25599974) Squamous cell lung carcinoma ( 28604730) Systolic blood pressure ( 30224653) Thyroid hormone levels ( 23408906) Triglyceride change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Type 1 diabetes ( 25751624 19430480 18840781) Type 2 diabetes ( 22885922 24509480 30054458 30297969 26818947 22961080 22158537 30718926 28869590)
Interacting Genes		27 interacting genes: BTRC FBXL17 GLI1 GLI2 GLI3 GLIS3 HDX HMGA1 HNRNPA1 ITCH LAMTOR3 LGALS3 MID1IP1 NCOA3 PEX26 PIAS1 QPRT RBPJ RCN3 RNF19A SAP18 SETDB1 STK36 ZNF219 ZNF263 ZNF446 ZNF764	3 interacting genes: CLNK ITCH SUFU
Entrez ID		51684	169792
HPRD ID		06124	13582
Ensembl ID		ENSG00000107882	ENSG00000107249
Uniprot IDs		A0A223LX15 Q9UMX1	A0A0S2Z689 Q1PHJ8 Q8NEA6
PDB IDs		1M1L 4BL8 4BL9 4BLA 4BLB 4BLD 4KM8 4KM9 4KMD 4KMH
Enriched GO Terms of Interacting Partners?
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