PCSK5 and NOTCH2NLA

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PCSK5	NOTCH2NLA
Description		proprotein convertase subtilisin/kexin type 5	notch 2 N-terminal like A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane Secretory Granule Integral Component Of Golgi Membrane	Extracellular Region Cytoplasm
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Peptide Binding	Notch Binding Calcium Ion Binding Protein Binding
	Biological Process	Kidney Development Renin Secretion Into Blood Stream Cardiac Septum Development Signal Peptide Processing Cell-cell Signaling Determination Of Left/right Symmetry Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Cytokine Biosynthetic Process Peptide Biosynthetic Process Embryonic Digestive Tract Development Embryonic Skeletal System Development Regulation Of Lipoprotein Lipase Activity Coronary Vasculature Development	Notch Signaling Pathway Cerebral Cortex Development Cell Differentiation Positive Regulation Of Notch Signaling Pathway
Pathways		NGF processing Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Ankylosing spondylitis ( 30946743) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Height ( 28552196 20881960 25282103 23563607 31562340) Inflammatory bowel disease ( 27569725) Intraocular pressure ( 29785010 31959993 30054594) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lead levels ( 26025379) Male fertility ( 22633400) Metabolite levels (5-HIAA) ( 23319000) Pursuit maintenance gain ( 29064472) Response to fenofibrate (adiponectin levels) ( 23149075) Systemic sclerosis ( 30247649) Takayasu arteritis ( 25604533) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Vascular brain injury ( 25188341) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		19 interacting genes: AMH APPBP2 ATN1 CACNA1A GLRX3 ITGA6 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 KRTAP5-9 LCE3C MEOX2 NOTCH2NLA NUFIP2 PMCH PTPRM REN STK16	242 interacting genes: ACY3 ADAMTSL3 ADAMTSL5 ADCK5 ALDH3B1 ALPI AQP1 AQP5 ARID3A ASPSCR1 ATG9A BCL6B BLCAP BMP7 C11orf87 C5orf60 CA6 CARHSP1 CATSPER1 CCDC26 CCDC93 CCER1 CD164 CDK5R1 CERK CHCHD3 CHDH CHIC2 CHRD CHRNG CLDN2 CLEC18A COL8A1 CRACR2A CRCT1 CREB5 CSF1 CST2 CST9L CTSG CTSZ CXCL16 CXCL5 DGCR6 DHRS1 DMRT3 DNAL4 DOCK2 EFNA3 EIF4E2 ELANE EPHB6 ESR2 FAAH FAM124B FAM71C FAM71E2 FAM74A4 FARS2 FASLG FBXL18 FBXW5 FOXB1 FRS3 GABRD GATA2 GEM GFOD1 GIP GLP1R GLRX3 GLYAT GNAI2 GNE GNMT GSTP1 GTF3C5 H2AC15 HBZ HCK HOXA1 HPCAL1 HSBP1 HSD3B7 HSPA12B HSPBP1 HSPD1 ICAM4 IFI30 IL2RG INPP5D ITGB2 ITGB5 JOSD1 KCTD15 KIF1A KLHL38 KLK8 KRT20 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-4 KRTAP13-3 KRTAP26-1 KRTAP3-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LIMS2 LIN7A LINC00526 LINC00656 LMO2 LNX1 LONRF3 LRCH4 LRFN4 MAPKBP1 MARK4 MATN3 MELTF MRGBP MRPL40 MTA1 MVP MXD3 MXI1 NAB2 NAXD NECTIN2 NECTIN3 NEU2 NMU NMUR2 NPBWR2 NPDC1 NPPB NR1D2 NUBP2 P2RX4 PCED1A PCED1B PCSK5 PDE9A PGLS PID1 PIGS PLPP2 PLSCR4 POLR2G POM121L8P POMGNT2 PRKAA2 PRPF31 PRPS2 PSMA1 PSMG2 PTGER3 PTPMT1 PTPN23 PVR QPRT R3HDM2 RAB3IL1 RAMP3 RCHY1 RECK RET RGL2 RPS28 RTN4RL1 SCNM1 SDCBP SELENOM SEMA4C SHFL SLC22A23 SLC23A1 SLC25A10 SLC25A6 SLC6A20 SMARCD2 SMARCE1 SMCP SMOC1 SNAI1 SPATA8 SPG7 SPINK2 SPRY1 STK16 TBC1D10C TBC1D16 TEDC2 THAP7 THEMIS2 TINAGL1 TLE5 TMEM150A TMEM231 TMEM41A TNIP3 TNK2 TNP2 TRIM27 TRIM42 TRPV6 TSPAN4 TXNDC5 UBQLN4 UTP23 UXT WDR25 WT1-AS XCL2 YIPF3 ZFYVE21 ZNF124 ZNF32 ZNF417 ZNF439 ZNF440 ZNF446 ZNF581 ZNF587 ZNF688
Entrez ID		5125	388677
HPRD ID		08985	14833
Ensembl ID		ENSG00000099139	ENSG00000264343
Uniprot IDs		Q92824	P0DPK4 Q7Z3S9
PDB IDs
Enriched GO Terms of Interacting Partners?
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