GLRX2 and TXNRD1

Number of citations of the paper that reports this interaction (PubMedID 14676218)
67

Data Source:
HPRD (in vitro)

		GLRX2	TXNRD1
Description		glutaredoxin 2	thioredoxin reductase 1
Image
GO Annotations	Cellular Component	Cell Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body Intracellular Membrane-bounded Organelle	Fibrillar Center Cell Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Arsenate Reductase (glutaredoxin) Activity Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Glutathione Disulfide Oxidoreductase Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Regulation Of Transcription, DNA-templated Glutathione Metabolic Process Apoptotic Process Aging Response To Temperature Stimulus Regulation Of Signal Transduction Response To Organic Substance Electron Transport Chain Cell Differentiation DNA Protection Response To Hydrogen Peroxide Cell Redox Homeostasis Response To Redox State Cellular Response To Superoxide	Mesoderm Formation Selenium Compound Metabolic Process Signal Transduction Cell Proliferation Nucleobase-containing Small Molecule Interconversion Regulation Of Lipid Metabolic Process Electron Transport Chain Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification
Pathways			PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes
Drugs		Glutathione	Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin adenine dinucleotide Spermidine Fotemustine motexafin gadolinium PX-12
Diseases
GWAS		Blood protein levels ( 29875488)	Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)
Interacting Genes		3 interacting genes: FBXO7 NUTF2 TXNRD1	10 interacting genes: DMRTC2 ESR1 ESR2 GLRX2 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP
Entrez ID		51022	7296
HPRD ID		12112	03068
Ensembl ID		ENSG00000023572	ENSG00000198431
Uniprot IDs		Q9NS18	B7Z2S5 Q16881
PDB IDs		2CQ9 2FLS 2HT9	1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?
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