TXNRD1 and POU2F1

Number of citations of the paper that reports this interaction (PubMedID 10383413)
10

Data Source:
BioGRID (pull down)

		TXNRD1	POU2F1
Description		thioredoxin reductase 1	POU class 2 homeobox 1
Image
GO Annotations	Cellular Component	Fibrillar Center Cell Nucleoplasm Cytoplasm Mitochondrion Cytosol Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex
	Molecular Function	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Mesoderm Formation Selenium Compound Metabolic Process Signal Transduction Cell Proliferation Nucleobase-containing Small Molecule Interconversion Regulation Of Lipid Metabolic Process Electron Transport Chain Cellular Response To Oxidative Stress Cell Redox Homeostasis Cellular Oxidant Detoxification	Cytokine-mediated Signaling Pathway Cell Differentiation SnRNA Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PPARA activates gene expression Metabolism of ingested H2SeO4 and H2SeO3 into H2Se Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates Metabolism of ingested MeSeO2H into MeSeH Uptake and function of diphtheria toxin TP53 Regulates Metabolic Genes	Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression
Drugs		Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin adenine dinucleotide Spermidine Fotemustine motexafin gadolinium PX-12
Diseases
GWAS		Blood protein levels ( 30072576) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Logical memory (delayed recall) in normal cognition ( 29274321) Toenail selenium levels ( 25343990)	Asthma ( 31619474) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Liver enzyme levels ( 18940312) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		10 interacting genes: DMRTC2 ESR1 ESR2 GLRX2 POU2F1 POU2F2 PPP1R16A THRA TXNDC17 TXNIP	49 interacting genes: APP AR BARD1 BRCA1 CEBPE CREB1 ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 VDR XRCC6
Entrez ID		7296	5451
HPRD ID		03068	01250
Ensembl ID		ENSG00000198431	ENSG00000143190
Uniprot IDs		B7Z2S5 Q16881	A0A024R8Y2 P14859
PDB IDs		1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB	1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU
Enriched GO Terms of Interacting Partners?
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