PARD6A and MARK4

Number of citations of the paper that reports this interaction (PubMedID 14676191)
55

Data Source:
HPRD (in vivo)

		PARD6A	MARK4
Description		par-6 family cell polarity regulator alpha	microtubule affinity regulating kinase 4
Image
GO Annotations	Cellular Component	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite	Gamma-tubulin Complex Cytoplasm Centrosome Microtubule Organizing Center Cytosol Microtubule Cytoskeleton Dendrite Midbody Ciliary Basal Body Neuron Projection
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding Rho GTPase Binding GTP-dependent Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Gamma-tubulin Binding Ubiquitin Binding Tau Protein Binding Tau-protein Kinase Activity
	Biological Process	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cellular Localization Bicellular Tight Junction Assembly Positive Regulation Of Protein Localization To Centrosome	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Protein Phosphorylation Cell Cycle Nervous System Development Intracellular Signal Transduction Positive Regulation Of Programmed Cell Death Cilium Organization Positive Regulation Of Cilium Assembly Regulation Of Centrosome Cycle Cell Division Ciliary Basal Body-plasma Membrane Docking Positive Regulation Of Protein Localization To Centrosome
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins	Anchoring of the basal body to the plasma membrane
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)	Advanced age-related macular degeneration ( 26691988) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Eosinophil counts ( 27863252) Granulocyte count ( 27863252) Hematocrit ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Parental longevity (father's attained age) ( 29227965) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		26 interacting genes: APP ATP5MG CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	28 interacting genes: CDC42 HGS HNRNPK HPS6 KHDRBS3 KRT31 KRT40 MAP2 MAP4 MAPT MTUS2 NEDD4 NOTCH2NLA ODF2 PARD6A PNMA1 PRKCG PRKCI PRNP PTBP1 RPTOR STK11 TUBA4A TUBB TUBG1 YWHAB YWHAH YWHAZ
Entrez ID		50855	57787
HPRD ID		06316	09402
Ensembl ID		ENSG00000102981	ENSG00000007047
Uniprot IDs		Q9NPB6	Q96L34
PDB IDs		1WMH	5ES1
Enriched GO Terms of Interacting Partners?
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