ROR2 and FZD2

Number of citations of the paper that reports this interaction (PubMedID 12839624)
233

Data Source:
HPRD (in vivo, in vitro)

		ROR2	FZD2
Description		receptor tyrosine kinase like orphan receptor 2	frizzled class receptor 2
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GO Annotations	Cellular Component	Microtubule Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Cytoplasm Plasma Membrane Focal Adhesion Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt-activated Receptor Activity
	Biological Process	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Smoothened Signaling Pathway JNK Cascade Multicellular Organism Development Nervous System Development Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Cell Migration BMP Signaling Pathway Embryonic Genitalia Morphogenesis Male Genitalia Development Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Embryonic Digit Morphogenesis Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Cell Fate Commitment Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Positive Regulation Of Synaptic Transmission, Glutamatergic Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Kinase C Activity Macrophage Migration	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Sensory Perception Of Smell Neuron Differentiation Epithelial Cell Differentiation Non-canonical Wnt Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of DNA-binding Transcription Factor Activity Hard Palate Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Inner Ear Receptor Cell Development Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Beta-catenin Destruction Complex Disassembly
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2	TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases		Brachydactyly, including: type A; type B; type D; type E Robinow syndrome
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Type 2 diabetes ( 25483131)	Pulse pressure ( 30224653)
Interacting Genes		43 interacting genes: C1orf94 CDC14A CDC25C CRX DAB1 DAZAP2 DUPD1 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP6 ERBB2 EYA2 FZD2 FZD5 IKBKG ILKAP MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PPM1A PPM1B PPM1F PPP3CB PRR20A PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS STYX TAB1 TPTE WNT5A ZMYM4	2 interacting genes: DLG4 ROR2
Entrez ID		4920	2535
HPRD ID		03822	02813
Ensembl ID		ENSG00000169071	ENSG00000180340
Uniprot IDs		Q01974	Q14332 Q86UZ8
PDB IDs		3ZZW 4GT4	6C0B
Enriched GO Terms of Interacting Partners?
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