NFKB2 and MAP3K8

Number of citations of the paper that reports this interaction (PubMedID 14743216)
300

Data Source:
HPRD (in vitro)

		NFKB2	MAP3K8
Description		nuclear factor kappa B subunit 2	mitogen-activated protein kinase kinase kinase 8
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Aging Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways		RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK - noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs		Acetylsalicylic acid Glucosamine HE3286 P54 NOX-700 SGN-30 Custirsen Andrographolide
Diseases
GWAS		Metabolite levels ( 23823483) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2	17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		4791	1326
HPRD ID		01239	01863
Ensembl ID		ENSG00000077150	ENSG00000107968
Uniprot IDs		Q00653	P41279 Q6FG25
PDB IDs		1A3Q 2D96 3DO7 4OT9 5ZMC	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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