MAP3K8 and NFKB1

Number of citations of the paper that reports this interaction (PubMedID 9950430)
70

Data Source:
BioGRID (protein complementation assay)
HPRD (in vitro, in vivo, two hybrid)

		MAP3K8	NFKB1
Description		mitogen-activated protein kinase kinase kinase 8	nuclear factor kappa B subunit 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nuclear Chromatin Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol I-kappaB/NF-kappaB Complex Secretory Granule Lumen Specific Granule Lumen
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Identical Protein Binding Actinin Binding Transcription Regulatory Region DNA Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Stimulatory C-type Lectin Receptor Signaling Pathway Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Negative Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Vitamin D Biosynthetic Process Membrane Protein Intracellular Domain Proteolysis Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cholesterol Transport Positive Regulation Of Type I Interferon Production Cellular Response To Stress Response To Cytokine Response To Muscle Stretch NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Neutrophil Degranulation Negative Regulation Of Interleukin-12 Biosynthetic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To DsRNA Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Angiotensin Positive Regulation Of MiRNA Metabolic Process
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection
Drugs			Acetylsalicylic acid Thalidomide Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen Andrographolide Triflusal
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Albumin-globulin ratio ( 29403010) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Copper levels ( 26025379) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 29124443 30604766) Glomerular filtration rate (creatinine) ( 26831199) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Inflammatory bowel disease ( 28067908) Lymphocyte percentage of white cells ( 27863252) Medication use (thyroid preparations) ( 31015401) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 21833088) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 27992413) Schizophrenia (treatment resistant) ( 22479419) Serum total protein level ( 29403010) Serum uric acid levels ( 29124443) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 31672989 30247649) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 23128233)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	104 interacting genes: ABCC2 APBB2 AR ATF3 BCL3 BRCA1 BTRC CDK9 CEBPB CFLAR CHUK COPB2 COPS5 CTNNB1 DNMT3L E2F1 ECSIT ELF1 ELF3 ESR1 ETS1 FBXW11 FOS G3BP2 GLUL GSK3B HDAC1 HMGA1 HMGA2 HMGB1 HSPA4 IKBKB IKBKG IL2RA IRF1 IRF2 IRF8 IRF9 ITGB3BP KAT5 KLF5 KPNA3 LYL1 MAP3K8 MEN1 MPP6 MTPN NCOA1 NCOA6 NCOR2 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NFRKB NKRF NOTCH1 NR3C1 NR4A1 PARP1 PCBD1 PDCD11 PELP1 PLD3 PML PPARG PPP4C PRKACA PSMD10 REL RELA RELB RGS14 RIPK1 RPS3 RSF1 RXRA SERPINA3 SF1 SIN3A SP1 SPAG9 SPI1 SPPL2A SRF STAT3 STAT6 TAB2 TFAP2A TNFSF11 TNIP1 TNIP2 TP53BP1 TP53BP2 TRIP4 TSC22D3 TXN UBE2D3 UBE2K UNC5CL YWHAQ YY1 ZBTB9
Entrez ID		1326	4790
HPRD ID		01863	01238
Ensembl ID		ENSG00000107968	ENSG00000109320
Uniprot IDs		P41279 Q6FG25	P19838
PDB IDs		4Y83 4Y85 5IU2	1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT
Enriched GO Terms of Interacting Partners?
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