NEDD9 and ZNF318

		NEDD9	ZNF318
Description		neural precursor cell expressed, developmentally down-regulated 9	zinc finger protein 318
Image			No pdb structure
GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Spindle Cytosol Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Nucleoplasm Cytosol
	Molecular Function	Protein Binding Protein Tyrosine Kinase Binding	Nucleic Acid Binding Zinc Ion Binding Protein Homodimerization Activity
	Biological Process	Cytoskeleton Organization Cell Cycle Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Positive Regulation Of Cell Migration Regulation Of Growth Actin Filament Bundle Assembly Cell Division Positive Regulation Of Protein Tyrosine Kinase Activity Actin Filament Reorganization Activation Of GTPase Activity Positive Regulation Of Substrate Adhesion-dependent Cell Spreading	Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Meiotic Cell Cycle
Pathways
Drugs
Diseases
GWAS		Childhood dental caries in permanent teeth ( 29931343) Coronary artery disease ( 29212778) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) HIV-1 susceptibility ( 22174851) Macular thickness ( 30535121) Prostate cancer ( 25217961) Small cell lung carcinoma ( 28604730)	Adult hearing difficulty ( 31564434) Autism spectrum disorder or schizophrenia ( 28540026) Chronotype ( 30696823) Diastolic blood pressure ( 30487518) Heel bone mineral density ( 30598549) Hypertension ( 30487518) Ischemic stroke ( 29531354) Mean arterial pressure ( 30487518) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 28739976 30487518 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Serum uric acid levels ( 30993211 29403010) Stroke ( 29531354) Systolic blood pressure ( 26390057 27841878 28739976 27618452 30487518 30578418) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urate levels ( 31578528) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		45 interacting genes: ABL1 APP AURKA BANP BCAR1 BCAR3 CDH1 CHAT CRK CRKL DIMT1 DMRTB1 ELSPBP1 FYN FZR1 ID2 ITCH LCK LYN MICAL1 NAB2 NCK1 NFKBIA NOTCH3 PIK3CA PRR20A PTK2 PTK2B PTPN11 PTPN12 PXN RAPGEF1 RBPMS REL RFX6 SH2D3C SMAD1 SMAD2 SMAD3 TCF3 TFCP2 TRIM27 TRIP6 ZNF318 ZYX	4 interacting genes: CUTA GFOD1 NEDD9 PPP1CC
Entrez ID		4739	24149
HPRD ID		11888	11707
Ensembl ID		ENSG00000111859	ENSG00000171467
Uniprot IDs		A0A024QZV9 A0A087WUD2 Q14511	Q5VUA4
PDB IDs		2L81 5X3S
Enriched GO Terms of Interacting Partners?
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