MAP3K10 and SH3RF1

Number of citations of the paper that reports this interaction (PubMedID 14504284)
24

Data Source:
HPRD (in vitro)

		MAP3K10	SH3RF1
Description		mitogen-activated protein kinase kinase kinase 10	SH3 domain containing ring finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity ATP Binding Protein Homodimerization Activity BHLH Transcription Factor Binding	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of JNK Cascade Protein Autophosphorylation	Neuron Migration Apoptotic Process Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Resting heart rate ( 27798624)	Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)
Interacting Genes		31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 MAP2K4 MAP3K21 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE	19 interacting genes: ADAM15 AKT1 AKT2 HERPUD1 KCNJ1 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 PAK2 PDCD6IP RAC1 RACGAP1 SEMA6A SIAH1 UBE2D1 UBE2D3 UBE2N
Entrez ID		4294	57630
HPRD ID		02533	15335
Ensembl ID		ENSG00000130758	ENSG00000154447
Uniprot IDs		Q02779	Q7Z6J0
PDB IDs		2RF0
Enriched GO Terms of Interacting Partners?
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