SH3RF1 and SEMA6A

Number of citations of the paper that reports this interaction (PubMedID 12421765)
39

Data Source:
HPRD (two hybrid)

		SH3RF1	SEMA6A
Description		SH3 domain containing ring finger 1	semaphorin 6A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Extracellular Space Integral Component Of Plasma Membrane Integral Component Of Membrane Axon
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Neuron Migration Apoptotic Process Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Neural Crest Cell Migration Apoptotic Process Cytoskeleton Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Animal Organ Morphogenesis Negative Regulation Of Angiogenesis Positive Regulation Of Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Negative Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway Negative Regulation Of Cell Adhesion Involved In Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Sprouting Angiogenesis Positive Regulation Of Neuron Migration
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Other semaphorin interactions
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Allergic rhinitis ( 22036096) Amyotrophic lateral sclerosis ( 19451621) Blood protein levels ( 29875488) Body mass index ( 27296613) Chronotype ( 30696823) Eosinophilic esophagitis ( 25017104) High chromosomal aberration frequency (chromatid type) ( 31586183) Periodontitis (DPAL) ( 24024966) Wegener's granulomatosis ( 23740775)
Interacting Genes		19 interacting genes: ADAM15 AKT1 AKT2 HERPUD1 KCNJ1 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 PAK2 PDCD6IP RAC1 RACGAP1 SEMA6A SIAH1 UBE2D1 UBE2D3 UBE2N	6 interacting genes: EVL ITSN2 SH3RF1 SORBS1 SORBS2 UBE2I
Entrez ID		57630	57556
HPRD ID		15335	06906
Ensembl ID		ENSG00000154447	ENSG00000092421
Uniprot IDs		Q7Z6J0	A0A0A0MQU6 Q9H2E6
PDB IDs
Enriched GO Terms of Interacting Partners?
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