Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
MAP3K5 and USP9X
Number of citations of the paper that reports this interaction (PubMedID
20005844
)
37
Data Source:
BioGRID
(enzymatic study)
MAP3K5
USP9X
Description
mitogen-activated protein kinase kinase kinase 5
ubiquitin specific peptidase 9 X-linked
Image
GO Annotations
Cellular Component
Cytosol
External Side Of Plasma Membrane
Protein-containing Complex
Protein Kinase Complex
IRE1-TRAF2-ASK1 Complex
Cytoplasm
Cytosol
Membrane
Growth Cone
Molecular Function
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Cysteine-type Endopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
Thiol-dependent Ubiquitinyl Hydrolase Activity
Co-SMAD Binding
Ubiquitinyl Hydrolase Activity
Lys48-specific Deubiquitinase Activity
Biological Process
MAPK Cascade
Activation Of MAPKK Activity
Response To Ischemia
Protein Phosphorylation
JNK Cascade
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Positive Regulation Of Cardiac Muscle Cell Apoptotic Process
Viral Process
Cellular Response To Stress
Cellular Response To Amino Acid Starvation
Response To Endoplasmic Reticulum Stress
P38MAPK Cascade
Wound Healing
Positive Regulation Of Apoptotic Process
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of JUN Kinase Activity
Innate Immune Response
Positive Regulation Of Myoblast Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Stress-activated MAPK Cascade
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Cellular Response To Hydrogen Peroxide
Cellular Response To Tumor Necrosis Factor
Endothelial Cell Apoptotic Process
Apoptotic Signaling Pathway
Programmed Necrotic Cell Death
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Neuron Death
Cellular Response To Reactive Nitrogen Species
Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
Negative Regulation Of Transcription By RNA Polymerase II
Neuron Migration
Protein Targeting To Peroxisome
Cell Cycle
Chromosome Segregation
Transforming Growth Factor Beta Receptor Signaling Pathway
Female Gamete Generation
Cell Migration
Protein Ubiquitination
Protein Deubiquitination
BMP Signaling Pathway
Regulation Of Circadian Rhythm
Cellular Protein Metabolic Process
Rhythmic Process
Axon Extension
Protein Stabilization
Cell Division
Protein K48-linked Deubiquitination
Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of DNA Demethylation
Pathways
Oxidative Stress Induced Senescence
Oxidative Stress Induced Senescence
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Ub-specific processing proteases
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Peroxisomal protein import
Peroxisomal protein import
Amyloid fiber formation
Drugs
Diseases
GWAS
HDL cholesterol (
30275531
)
Migraine (
27322543
)
Interacting Genes
65 interacting genes:
AKT1
ARRB1
ARRB2
AURKA
CCND2
CDC25A
CDK4
CDK6
CDKN1A
CDKN2A
CREBBP
DAB2IP
DAXX
DMD
DUSP19
EIF2AK2
EP300
ERN1
FGFR4
FZR1
GADD45B
GEMIN5
GLIS2
GLRX
GSTM1
HSPA1A
IGF1R
JAK2
LATS2
MAP2K3
MAP2K4
MAP2K6
MAP2K7
MAP3K2
MAP3K3
MAP3K6
MAP3K7
MAPK8IP3
MBP
NEDD4
NEDD4L
NF2
PDCD6
PPP3R1
PPP5C
PTPN11
QARS1
RAF1
SFN
SIAH1
STK11
TEAD2
TERT
TNFAIP3
TNNT2
TPD52L1
TRAF2
TRAF5
TRAF6
TXN
USP9X
YWHAE
YWHAH
YWHAQ
YWHAZ
21 interacting genes:
AFDN
ALDH1A3
BCL9
CTNNB1
DCX
ERG
FBXW7
GPSM1
MAP3K5
MCL1
PEX5
PSD4
RNF115
SMAD2
SMAD4
SMN2
SMURF1
STIL
TDRD3
UBC
VHL
Entrez ID
4217
8239
HPRD ID
03904
02091
Ensembl ID
ENSG00000197442
ENSG00000124486
Uniprot IDs
Q99683
Q6P468
Q86X58
Q93008
PDB IDs
2CLQ
3VW6
4BF2
4BHN
4BIB
4BIC
4BID
4BIE
5ULM
5UOR
5UOX
5UP3
5V19
5V24
5VIL
5VIO
6E2M
6E2N
6E2O
6EJL
6OYT
6OYW
5VBD
5WCH
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?