MDK and PTPRZ1

Number of citations of the paper that reports this interaction (PubMedID 10212223)
73

Data Source:
HPRD (in vivo, in vitro)

		MDK	PTPRZ1
Description		midkine	protein tyrosine phosphatase receptor type Z1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Projection Collagen-containing Extracellular Matrix	Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Plasma Membrane Synapse Perineuronal Net
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding
	Biological Process	Behavioral Fear Response Leukocyte Chemotaxis Involved In Inflammatory Response T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Adrenal Gland Development Positive Regulation Of Cell Migration Defecation Regulation Of Chondrocyte Differentiation Tissue Regeneration Response To Drug Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Regulation Of Bone Remodeling Oogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division Positive Regulation Of Cartilage Development Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Neutrophil Extravasation Positive Regulation Of Interleukin-12 Secretion Positive Regulation Of Neuron Migration	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Axonogenesis Central Nervous System Development Learning Or Memory Cytokine-mediated Signaling Pathway Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		NOTCH2 Activation and Transmission of Signal to the Nucleus	Other interleukin signaling
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling miserable ( 29500382) Immunoglobulin A ( 20694011) Schizophrenia ( 28991256 29483656 30285260)	Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)
Interacting Genes		20 interacting genes: ALK FBXO7 JAK1 JAK2 LRP1 LRP2 LRP6 LRP8 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4	13 interacting genes: AASS ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN TNR
Entrez ID		4192	5803
HPRD ID		01200	01481
Ensembl ID		ENSG00000110492	ENSG00000106278
Uniprot IDs		P21741	B4DFE7 P23471
PDB IDs		1MKC 1MKN	3JXF 3S97 5AWX 5H08
Enriched GO Terms of Interacting Partners?
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