MDK and LRP1

Number of citations of the paper that reports this interaction (PubMedID 10772929)
36

Data Source:
HPRD (in vivo, in vitro)

		MDK	LRP1
Description		midkine	LDL receptor related protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cell Projection Collagen-containing Extracellular Matrix	Cell Nucleus Lysosomal Membrane Early Endosome Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Insulin-responsive Compartment Neuronal Cell Body Receptor Complex Axonal Growth Cone Apical Part Of Cell Plasma Membrane Protein Complex Postsynaptic Golgi Apparatus
	Molecular Function	Protein Binding Growth Factor Activity Heparin Binding Chondroitin Sulfate Binding Heparan Sulfate Binding	Amyloid-beta Binding Protease Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Coreceptor Activity Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Lipoprotein Particle Receptor Binding
	Biological Process	Behavioral Fear Response Leukocyte Chemotaxis Involved In Inflammatory Response T Cell Activation Involved In Immune Response Positive Regulation Of Leukocyte Chemotaxis Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Notch Signaling Pathway Nervous System Development Short-term Memory Response To Wounding Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Keratinocyte Proliferation Positive Regulation Of Neuron Projection Development Response To Auditory Stimulus Dentate Gyrus Development Cerebellar Granular Layer Development Cerebral Cortex Development Cell Differentiation Negative Regulation Of Ossification Adrenal Gland Development Positive Regulation Of Cell Migration Defecation Regulation Of Chondrocyte Differentiation Tissue Regeneration Response To Drug Negative Regulation Of Neuron Apoptotic Process Estrous Cycle Positive Regulation Of T Cell Differentiation Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Regulation Of Bone Remodeling Oogenesis Positive Regulation Of Oligodendrocyte Differentiation Positive Regulation Of Inflammatory Response Regulation Of Behavior Response To Glucocorticoid Positive Regulation Of Cell Division Positive Regulation Of Cartilage Development Positive Regulation Of Smooth Muscle Cell Chemotaxis Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Inflammatory Response To Wounding Positive Regulation Of Inflammatory Response To Wounding Glial Cell Projection Elongation Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Positive Regulation Of Neural Precursor Cell Proliferation Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Neutrophil Extravasation Positive Regulation Of Interleukin-12 Secretion Positive Regulation Of Neuron Migration	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Aging Cell Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cerebral Cortex Development Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Protein Binding Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Catabolic Process Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of Collateral Sprouting Of Injured Axon Positive Regulation Of Phagocytosis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Focal Adhesion Assembly Chemoattraction Of Axon Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Schwann Cell Migration Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cholesterol Import Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Metallopeptidase Activity Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		NOTCH2 Activation and Transmission of Signal to the Nucleus	Scavenging of heme from plasma Retinoid metabolism and transport
Drugs			Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Coagulation Factor IX Human
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Feeling miserable ( 29500382) Immunoglobulin A ( 20694011) Schizophrenia ( 28991256 29483656 30285260)	Abdominal aortic aneurysm ( 27899403 22055160) Adult asthma ( 30787307) Asthma ( 27182965 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 21666692 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565)
Interacting Genes		20 interacting genes: ALK FBXO7 JAK1 JAK2 LRP1 LRP2 LRP6 LRP8 MAPK6 NCL PTPRZ1 RPL18A SDC1 SDC3 SDC4 SRPK2 STAT1 TGM1 TSPAN1 UBQLN4	66 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NOS1AP PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		4192	4035
HPRD ID		01200	00138
Ensembl ID		ENSG00000110492	ENSG00000123384
Uniprot IDs		P21741	Q07954 Q59FG2
PDB IDs		1MKC 1MKN	1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?
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