MCM6 and IL36RN

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		MCM6	IL36RN
Description		minichromosome maintenance complex component 6	interleukin 36 receptor antagonist
Image
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm MCM Complex	Extracellular Region Extracellular Space
	Molecular Function	DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Identical Protein Binding Single-stranded DNA-dependent ATP-dependent 3'-5' DNA Helicase Activity	Cytokine Activity Interleukin-1 Receptor Binding Interleukin-1 Receptor Antagonist Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Mitotic DNA Replication	Negative Regulation Of Cytokine-mediated Signaling Pathway Inflammatory Response To Antigenic Stimulus Inflammatory Response Cytokine-mediated Signaling Pathway Antifungal Humoral Response Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Innate Immune Response Cellular Response To Lipopolysaccharide Negative Regulation Of Interferon-gamma Secretion
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Interleukin-36 pathway
Drugs
Diseases
GWAS		Body mass index ( 25673413) Hip circumference ( 25673412) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)	Menstruation quality of life impact (dysmenorrhea) ( 29855537) Pain medicine use during menstruation ( 29855537) Stroke ( 26089329)
Interacting Genes		36 interacting genes: C2CD6 CCNA1 CDC45 CDC7 CDKN2A CDT1 CHEK1 CRLS1 DBF4 ESCO2 FAM161A GMNN HSPB1 IL36RN ING5 MCM10 MCM2 MCM3 MCM4 MCM7 MCM8 MCMBP MLLT3 MTDH NUDT2 ORC1 ORC2 ORC4 ORC6 PSMA1 RPA1 SCNM1 SMC1A SNRPB2 UBE3A ZBTB9	7 interacting genes: MCM6 REL SKIL SSBP2 SSBP3 SSBP4 ZNF512B
Entrez ID		4175	26525
HPRD ID		03485	16112
Ensembl ID		ENSG00000076003	ENSG00000136695
Uniprot IDs		Q14566	A0A024R518 Q9UBH0
PDB IDs		2KLQ 2LE8	4P0J 4P0K 4P0L
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?