MATK and FRS3

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		MATK	FRS3
Description		megakaryocyte-associated tyrosine kinase	fibroblast growth factor receptor substrate 3
Image
GO Annotations	Cellular Component	Cytosol Membrane	Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding
	Biological Process	Protein Phosphorylation Positive Regulation Of Cell Proliferation Peptidyl-tyrosine Phosphorylation ERBB2 Signaling Pathway	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway
Pathways		Downregulation of ERBB2 signaling	FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Menarche (age at onset) ( 25231870)
Interacting Genes		20 interacting genes: AKT1 CACNA1A CD36 ERBB2 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC	28 interacting genes: ADAMTSL4 BMPR2 CBY2 DDX5 FGFR1 GATA1 GRB14 GRB2 KARS1 MAPK1 MATK NOTCH2NLA NTRK1 NTRK2 NUMB PLSCR1 PRKCI PTPN11 RFX6 RND1 SH2B1 SOCS6 SPRY2 TCF4 TLE5 TNS1 TRIP6 VASP
Entrez ID		4145	10817
HPRD ID		02496	06373
Ensembl ID		ENSG00000007264	ENSG00000137218
Uniprot IDs		F1T0G6 P42679	A0A140VJJ7 O43559
PDB IDs		1JWO 1X6G 3US4	2KUP 2KUQ 2YS5 2YT2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?