LGALS3 and CUBN

Number of citations of the paper that reports this interaction (PubMedID 11856751)
4

Data Source:
HPRD (in vitro)

		LGALS3	CUBN
Description		galectin 3	cubilin
Image
GO Annotations	Cellular Component	Immunological Synapse Extracellular Region Extracellular Space Nucleus Spliceosomal Complex Cytoplasm Mitochondrial Inner Membrane Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Ficolin-1-rich Granule Membrane	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Brush Border Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function	RNA Binding Protein Phosphatase Inhibitor Activity Protein Binding IgE Binding Protein Phosphatase Binding Carbohydrate Binding Chemoattractant Activity Laminin Binding	Calcium Ion Binding Protein Binding Drug Binding Cobalamin Binding Signaling Receptor Activity Cargo Receptor Activity Protein Homodimerization Activity
	Biological Process	Monocyte Chemotaxis MRNA Processing RNA Splicing Neutrophil Chemotaxis Epithelial Cell Differentiation Positive Regulation Of Protein Complex Assembly Regulation Of T Cell Proliferation Neutrophil Degranulation Innate Immune Response Regulation Of Myeloid Cell Differentiation Negative Regulation Of Endocytosis Eosinophil Chemotaxis Macrophage Chemotaxis Negative Regulation Of T Cell Receptor Signaling Pathway Positive Chemotaxis Regulation Of T Cell Apoptotic Process Mononuclear Cell Migration Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Calcium Ion Import Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Protein Tyrosine Phosphatase Activity Negative Regulation Of Immunological Synapse Formation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Positive Regulation Of Dendritic Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Tissue Homeostasis Receptor-mediated Endocytosis Cholesterol Metabolic Process Cobalamin Metabolic Process Response To Bacterium Cobalamin Transport High-density Lipoprotein Particle Clearance Vitamin D Metabolic Process Lipoprotein Transport
Pathways		Neutrophil degranulation Advanced glycosylation endproduct receptor signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX2 regulates genes involved in differentiation of myeloid cells	Cobalamin (Cbl, vitamin B12) transport and metabolism Vitamin D (calciferol) metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective CUBN causes hereditary megaloblastic anemia 1 HDL clearance
Drugs		2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide Lactose	Hydroxocobalamin
Diseases
GWAS		Blood protein levels ( 30072576 28240269) Blood protein levels in cardiovascular risk ( 28369058) Protein biomarker ( 23056639) Testicular germ cell tumor ( 28604728)	Binge eating behaviour in bipolar disorder ( 29391396) Cholesterol, total ( 24097068) Colorectal cancer ( 25990418) Folate pathway vitamin levels ( 19303062 19744961) High density lipoprotein cholesterol levels ( 30498476) Homocysteine levels ( 23824729) Metabolite levels ( 23823483) Microalbuminuria ( 26631737 31511532) Molybdenum levels ( 26025379) Platelet distribution width ( 27863252) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Quantitative traits ( 19197348) Superior temporal gyrus volume ( 31530798) Total cholesterol levels ( 28334899) Total grey matter volume ( 31530798) Urate levels ( 31578528) Urinary albumin excretion ( 21355061 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 26631737 31630189 30910378 27650483 31511532) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Vitamin B levels in ischemic stroke ( 25147783) Whole-brain volume ( 21116278)
Interacting Genes		25 interacting genes: APP C1GALT1C1 CSNK1A1 CSNK2A1 CSNK2A2 CUBN CYHR1 ELN FCGR2A GEMIN4 GOLGA2 LGALS3BP LIM2 MCPH1 MEFV MMP2 MYOC PPIG PRR13 SS18L1 SUFU TRIM17 TRIM22 TRIM23 TRIM6	9 interacting genes: ALB BRCA1 CBL CBLIF GC LGALS3 LRP2 SCGB1A1 TF
Entrez ID		3958	8029
HPRD ID		01090	04296
Ensembl ID		ENSG00000131981	ENSG00000107611
Uniprot IDs		A0A024R693 P17931	O60494
PDB IDs		1A3K 1KJL 1KJR 2NMN 2NMO 2NN8 2XG3 3AYA 3AYC 3AYD 3AYE 3T1L 3T1M 3ZSJ 3ZSK 3ZSL 3ZSM 4BLI 4BLJ 4BM8 4JC1 4JCK 4LBJ 4LBK 4LBL 4LBM 4LBN 4LBO 4R9A 4R9B 4R9C 4R9D 4RL7 4XBN 5E88 5E89 5E8A 5EXO 5H9P 5H9R 5IUQ 5NF7 5NF9 5NFA 5NFB 5NFC 5OAX 5ODY 6B8K 6EOG 6EOL 6EXY 6EYM 6F2Q 6F6Y 6FK2 6FOF 6G0V 6H64 6I74 6I75 6I76 6I77 6I78 6QGE 6QGF 6QLN 6QLO 6QLP 6QLQ 6QLR 6QLS 6QLT 6QLU 6RHL 6RHM	3KQ4 6GJE
Enriched GO Terms of Interacting Partners?
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