CUBN and CBLIF

Number of citations of the paper that reports this interaction (PubMedID 9572993)
25

Data Source:
HPRD (in vitro)

		CUBN	CBLIF
Description		cubilin	cobalamin binding intrinsic factor
Image
GO Annotations	Cellular Component	Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Clathrin-coated Pit Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Extrinsic Component Of External Side Of Plasma Membrane Brush Border Membrane Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Endosome Microvillus Apical Plasma Membrane Lysosomal Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Drug Binding Cobalamin Binding Signaling Receptor Activity Cargo Receptor Activity Protein Homodimerization Activity	Cobalamin Binding
	Biological Process	Tissue Homeostasis Receptor-mediated Endocytosis Cholesterol Metabolic Process Cobalamin Metabolic Process Response To Bacterium Cobalamin Transport High-density Lipoprotein Particle Clearance Vitamin D Metabolic Process Lipoprotein Transport	Cobalt Ion Transport Cobalamin Metabolic Process Cobalamin Transport
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Vitamin D (calciferol) metabolism Defective AMN causes hereditary megaloblastic anemia 1 Defective CUBN causes hereditary megaloblastic anemia 1 HDL clearance	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective GIF causes intrinsic factor deficiency Defective AMN causes hereditary megaloblastic anemia 1 Defective CUBN causes hereditary megaloblastic anemia 1
Drugs		Hydroxocobalamin
Diseases
GWAS		Binge eating behaviour in bipolar disorder ( 29391396) Cholesterol, total ( 24097068) Colorectal cancer ( 25990418) Folate pathway vitamin levels ( 19303062 19744961) High density lipoprotein cholesterol levels ( 30498476) Homocysteine levels ( 23824729) Metabolite levels ( 23823483) Microalbuminuria ( 26631737 31511532) Molybdenum levels ( 26025379) Platelet distribution width ( 27863252) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Quantitative traits ( 19197348) Superior temporal gyrus volume ( 31530798) Total cholesterol levels ( 28334899) Total grey matter volume ( 31530798) Urate levels ( 31578528) Urinary albumin excretion ( 21355061 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 26631737 31630189 30910378 27650483 31511532) Urinary albumin-to-creatinine ratio in diabetes ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Vitamin B levels in ischemic stroke ( 25147783) Whole-brain volume ( 21116278)
Interacting Genes		9 interacting genes: ALB BRCA1 CBL CBLIF GC LGALS3 LRP2 SCGB1A1 TF	2 interacting genes: CBL CUBN
Entrez ID		8029	2694
HPRD ID		04296	02024
Ensembl ID		ENSG00000107611	ENSG00000134812
Uniprot IDs		O60494	P27352
PDB IDs		3KQ4 6GJE	2CKT 2PMV 3KQ4
Enriched GO Terms of Interacting Partners?
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