RHOG and IQGAP2

Number of citations of the paper that reports this interaction (PubMedID 12376551)
55

Data Source:
HPRD (in vitro)

		RHOG	IQGAP2
Description		ras homolog family member G	IQ motif containing GTPase activating protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Cell Cortex Secretory Granule Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Extracellular Exosome
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	Actin Binding GTPase Inhibitor Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Rho GTPase Binding Rac GTPase Binding Actin Filament Binding Arp2/3 Complex Binding
	Biological Process	Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Motor Neuron Axon Guidance Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Rac Protein Signal Transduction Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Neutrophil Degranulation Engulfment Of Apoptotic Cell Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Activation Of GTPase Activity Regulation Of Ruffle Assembly Regulation Of Neutrophil Migration Positive Regulation Of Protein Localization To Plasma Membrane	Signal Transduction Negative Regulation Of GTPase Activity Arp2/3 Complex-mediated Actin Nucleation Neutrophil Degranulation Thrombin-activated Receptor Signaling Pathway
Pathways		GPVI-mediated activation cascade PIP3 activates AKT signaling Rho GTPase cycle Constitutive Signaling by Aberrant PI3K in Cancer RHO GTPases activate KTN1 Neutrophil degranulation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	RHO GTPases activate IQGAPs Neutrophil degranulation
Drugs
Diseases
GWAS			Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 27863252) Late-onset Alzheimer's disease ( 27770636) Mean platelet volume ( 27863252) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)
Interacting Genes		19 interacting genes: ARHGDIA ARHGDIG DOCK1 ECT2 ELMO1 ELMO2 ELMOD2 IQGAP2 KTN1 MAP3K11 MCF2 MCF2L PLD1 SMAD1 SMAD4 TGFBR1 VAV1 VAV2 VAV3	6 interacting genes: ACTR2 ALG8 CALM1 CDC42 RAC1 RHOG
Entrez ID		391	10788
HPRD ID		01537	09253
Ensembl ID		ENSG00000177105	ENSG00000145703
Uniprot IDs		P84095 Q6ICQ8	B7Z7U6 B7Z7X2 Q13576 Q59HA3
PDB IDs			3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?
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