KCNJ2 and PATJ

Number of citations of the paper that reports this interaction (PubMedID 16637659)
25

Data Source:
HPRD (in vitro)

		KCNJ2	PATJ
Description		potassium inwardly rectifying channel subfamily J member 2	PATJ crumbs cell polarity complex component
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine	Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Apical Plasma Membrane Cell Junction Centriolar Satellite Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization	Protein Binding
	Biological Process	Potassium Ion Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Regulation Of Ion Transmembrane Transport Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cardiac Conduction Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Cardiac Muscle Cell Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Intracellular Signal Transduction Bicellular Tight Junction Assembly
Pathways		Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Atrial fibrillation Short QT syndrome Andersen-Tawil syndrome (ATS)
GWAS		Adolescent idiopathic scoliosis (severe) ( 24023777) Atrial fibrillation ( 29892015) Birth weight ( 31043758) Chin dimples ( 27182965) Dentures ( 31235808) Depressive episodes in bipolar disorder ( 26297903) Early cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Hip circumference adjusted for BMI ( 25673412) Lung function (forced vital capacity) ( 24929828) Macular thickness ( 30535121) Metabolite levels ( 23823483) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Prudent dietary pattern ( 28644415) Pulmonary function (smoking interaction) ( 23284291) QT interval ( 30679814 24952745 19305409) Refractive error ( 23396134) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142) Thyrotoxic hypokalemic periodic paralysis and Graves disease ( 31050781) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30582445) Excessive daytime sleepiness ( 27992416) Sleep traits (multi-trait analysis) ( 27992416) Type 2 diabetes ( 30297969)
Interacting Genes		14 interacting genes: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 KCNJ11 KCNJ16 KCNJ4 KCNJ8 PATJ TRAK2	28 interacting genes: ADGRB1 ASIC3 CACNG2 CLDN1 CNKSR2 CRB3 CRIPT DDX18 GLS2 GRIN2A GRIN2B GRIN2C GRIN2D KCNA4 KCNJ10 KCNJ15 KCNJ2 KIF1B MAPK12 MPP5 NLGN2 NRXN2 PARD3 PAX6 PRDM16 SCN4A SCN5A TJP3
Entrez ID		3759	10207
HPRD ID		02815	04434
Ensembl ID		ENSG00000123700	ENSG00000132849
Uniprot IDs		P63252
PDB IDs
Enriched GO Terms of Interacting Partners?
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