JUN and PPP4C

Number of citations of the paper that reports this interaction (PubMedID 9837938)
21

Data Source:
BioGRID (pull down)

		JUN	PPP4C
Description		Jun proto-oncogene, AP-1 transcription factor subunit	protein phosphatase 4 catalytic subunit
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Cytosol Transcriptional Repressor Complex Transcription Factor AP-1 Complex	Nucleoplasm Microtubule Organizing Center Cytosol Plasma Membrane Protein Phosphatase 4 Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity RNA Binding GTPase Activator Activity Protein Binding Transcription Factor Binding Enzyme Binding Ubiquitin Protein Ligase Binding CAMP Response Element Binding Identical Protein Binding Transcription Regulatory Region DNA Binding Ubiquitin-like Protein Ligase Binding Protein-containing Complex Binding R-SMAD Binding HMG Box Domain Binding	NF-kappaB-inducing Kinase Activity Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Liver Development Positive Regulation Of Endothelial Cell Proliferation Outflow Tract Morphogenesis Transcription By RNA Polymerase II Transforming Growth Factor Beta Receptor Signaling Pathway Ras Protein Signal Transduction Aging Learning Circadian Rhythm Negative Regulation Of Cell Proliferation Response To Radiation Response To Mechanical Stimulus Response To Organic Substance Positive Regulation Of Epithelial Cell Migration Monocyte Differentiation Axon Regeneration Negative Regulation Of Protein Autophosphorylation Response To Lipopolysaccharide Cellular Response To Hormone Stimulus Cellular Response To Stress Response To Cytokine Cellular Response To Reactive Oxygen Species Leading Edge Cell Differentiation Response To Muscle Stretch Fc-epsilon Receptor Signaling Pathway Regulation Of Cell Proliferation Response To Drug Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Transcription Positive Regulation By Host Of Viral Transcription Positive Regulation Of Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of DNA Replication Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Regulation Of DNA-binding Transcription Factor Activity Cellular Response To Potassium Ion Starvation Response To CAMP Regulation Of Cell Cycle Membrane Depolarization SMAD Protein Signal Transduction Eyelid Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cadmium Ion Cellular Response To Calcium Ion Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of DNA-templated Transcription, Initiation	Protein Dephosphorylation Regulation Of Double-strand Break Repair Via Homologous Recombination NIK/NF-kappaB Signaling
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) FCERI mediated MAPK activation Activation of the AP-1 family of transcription factors Activation of anterior HOX genes in hindbrain development during early embryogenesis MAPK6/MAPK4 signaling TP53 Regulates Transcription of DNA Repair Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression WNT5:FZD7-mediated leishmania damping	Processing of DNA double-strand break ends
Drugs		Vinblastine Pseudoephedrine Irbesartan Arsenic trioxide LGD-1550
Diseases
GWAS		Cognitive performance ( 19734545) Night sleep phenotypes ( 27126917)	Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Mean corpuscular volume ( 29403010) Medication use (diuretics) ( 31015401) Schizophrenia ( 25056061 29483656)
Interacting Genes		179 interacting genes: ABL1 APLP2 APP AR ARRB1 ATF1 ATF2 ATF3 ATF4 BATF BATF2 BBS7 BCL3 BCL6 BLM BRCA1 CASP9 CCND1 CEBPE CEBPG CLINT1 COP1 COPS5 CREB3 CREB5 CREBBP CSNK2A1 DACH1 DDIT3 DDX21 DHX9 DNMT3L EDF1 EGR1 ELF3 ELOF1 EN1 EP300 EPAS1 ERG ESR1 ETS1 ETS2 ETV1 ETV4 EWSR1 FBXW7 FOS FOSB FOSL1 FOSL2 GATA2 GOPC GSK3B GTF2B GTF2E2 GTF2F1 GTF2F2 HCFC1 HDAC3 HDAC9 HDGF HHEX HIF1A HMGA1 HNRNPM HOXA9 HOXC8 HSP90AA1 HSPA8 IKBKB IRAK1 ITCH ITPK1 JDP2 KLF5 KMT2C KPNA2 M6PR MACF1 MAF MAFB MAP2K4 MAP2K7 MAPK1 MAPK10 MAPK11 MAPK14 MAPK3 MAPK8 MAPK9 MAPKAPK5 MAPRE3 MBD3 MDM2 MOK MTA1 MYBBP1A MYOD1 NACA NAT14 NCOA1 NCOA2 NCOA3 NCOA6 NCOR2 NEDD4 NELFB NFE2L1 NFE2L2 NFYA NR3C1 NR5A1 NRIP1 NTRK3 PACS1 PHOX2A PIAS1 PIAS2 PIN1 POU1F1 PPARG PPP3CB PPP4C PRKD1 PRKDC PRRC2A RB1 RBM39 RELA RNF187 RPL18A RPS6KA2 RUNX1 RUNX2 SKI SMAD2 SMAD3 SMAD4 SMARCD1 SMARCD3 SNAPC5 SNIP1 SNRK SOX10 SOX8 SP1 SPI1 SPIB STAT1 STAT3 STAT4 STRN4 SUMO1 SUMO2 SUMO3 SUMO4 TAF1 TAF4 TBP TCF20 TCF4 TDG TGIF1 TOP1 TOP2A TPM1 TPM2 TRAF2 TRIP4 TSC22D3 TSG101 UBB UBC UBE2I USP6 VAV1 VDR ZBTB7C	21 interacting genes: CCDC6 DHX38 HDAC3 IGBP1 JUN NFKB1 PPP2R1A PPP2R5D PPP4R1 PPP4R2 PPP4R3B PPP4R4 REL RELA RPA2 TIPRL TK1 TMSB4X TP53 TRAF6 TRIM28
Entrez ID		3725	5531
HPRD ID		01302	03615
Ensembl ID		ENSG00000177606	ENSG00000149923
Uniprot IDs		P05412	A0A024R625 P60510
PDB IDs		1A02 1FOS 1JNM 1JUN 1S9K 1T2K 5FV8 5T01
Enriched GO Terms of Interacting Partners?
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