APLP1 and ING5

Number of citations of the paper that reports this interaction (PubMedID 15383276)
142

Data Source:
BioGRID (two hybrid)

		APLP1	ING5
Description		amyloid beta precursor like protein 1	inhibitor of growth family member 5
Image
GO Annotations	Cellular Component	Basement Membrane Plasma Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm MOZ/MORF Histone Acetyltransferase Complex
	Molecular Function	Protein Binding Heparin Binding Alpha-2A Adrenergic Receptor Binding Alpha-2B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Identical Protein Binding Transition Metal Ion Binding	Chromatin Binding Protein Binding Methylated Histone Binding Metal Ion Binding
	Biological Process	Endocytosis Apoptotic Process Cell Adhesion Nervous System Development Animal Organ Morphogenesis Cellular Response To Norepinephrine Stimulus Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway	DNA Replication Protein Acetylation Negative Regulation Of Cell Proliferation Positive Regulation Of Apoptotic Process Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Growth Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Apoptotic Signaling Pathway
Pathways			HATs acetylate histones Regulation of TP53 Activity through Acetylation
Drugs		Zinc Copper
Diseases
GWAS		Severe influenza A (H1N1) infection ( 26379185)	Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433)
Interacting Genes		42 interacting genes: ANXA7 APBB1 CDK4 CDKN1A CDKN2C CRCT1 CSNK2B DAB1 DAB2 EEF1A1 EIF2S2 GDF9 GSTM4 HAP1 HLA-DQA1 HSPE1 ING5 KAT5 LRIF1 MPHOSPH6 NACA PCDHA4 PHF10 PIN1 PNP PRNP RAP1B RBM48 RCC1 SAT1 SETDB1 SMN1 SNCA STX5 TCF21 TK1 TMSB4X TOE1 TSC22D1 UTP14A VIM ZNF24	35 interacting genes: APC APLP1 ARFIP2 BARD1 C3orf62 CCDC33 CDCA7L CDK2 CDKN1A CEP126 CEP44 DEUP1 EP300 FAM118B GCSH HAP1 HGS HTT ICA1 IKZF3 JADE2 KRT40 KRTAP10-7 KXD1 MBIP MCM6 MEST NAV2 PCM1 PRMT5 SMARCE1 TADA3 TAF1D TP53 VIM
Entrez ID		333	84289
HPRD ID		00102	16348
Ensembl ID		ENSG00000105290	ENSG00000168395
Uniprot IDs		P51693	A0A1B0GW41 Q8WYH8
PDB IDs		3PMR 3Q7G 3Q7L 3QMK 4RD9 4RDA	3C6W 5ME8 5MTO
Enriched GO Terms of Interacting Partners?
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