PRMT1 and ASH2L

Number of citations of the paper that reports this interaction (PubMedID 21285357)
13

Data Source:
BioGRID (enzymatic study)

		PRMT1	ASH2L
Description		protein arginine methyltransferase 1	ASH2 like, histone lysine methyltransferase complex subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome	Nucleus Nucleoplasm Nuclear Euchromatin Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H4-R3 Specific) Mitogen-activated Protein Kinase P38 Binding S-adenosyl-L-methionine Binding	Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding Euchromatin Binding
	Biological Process	In Utero Embryonic Development Protein Methylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Neuron Projection Development Histone H4-R3 Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hemoglobin Biosynthetic Process Protein Homooligomerization Positive Regulation Of P38MAPK Cascade	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly
Pathways		RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Schizophrenia ( 29483656)	Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)
Interacting Genes		100 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EIF4A1 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GPATCH2L GRHL3 GRIP1 H3C1 H4-16 H4C14 HABP4 HNF4A HNRNPA1 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 IMPDH2 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MBP MECOM MED31 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PRMT8 QKI RBM15 RELA RNF187 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 STAT1 STAT5A STUB1 SUPT5H SYNCRIP TBX6 TERF2 THRB TP53 TRIM48 UBAP2L UBE4B VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZMYM5 ZNF451	25 interacting genes: BARD1 BRCA1 CHD8 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1
Entrez ID		3276	9070
HPRD ID		04257	05309
Ensembl ID		ENSG00000126457	ENSG00000129691
Uniprot IDs		Q99873	B4DPT1 F5H8F7 Q9UBL3
PDB IDs		6NT2	3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ
Enriched GO Terms of Interacting Partners?
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