PRMT1 and BTG2

Number of citations of the paper that reports this interaction (PubMedID 8663146)
128

Data Source:
BioGRID (pull down, biochemical)
HPRD (in vitro)

		PRMT1	BTG2
Description		protein arginine methyltransferase 1	BTG anti-proliferation factor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Methylosome	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein Methyltransferase Activity Methyl-CpG Binding Protein-arginine N-methyltransferase Activity Enzyme Binding Protein-arginine Omega-N Monomethyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H4-R3 Specific) Mitogen-activated Protein Kinase P38 Binding S-adenosyl-L-methionine Binding	DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding
	Biological Process	In Utero Embryonic Development Protein Methylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Neuron Projection Development Histone H4-R3 Methylation Positive Regulation Of Erythrocyte Differentiation Regulation Of Megakaryocyte Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Hemoglobin Biosynthetic Process Protein Homooligomerization Positive Regulation Of P38MAPK Cascade	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Protein Methylation Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Cell Proliferation Associative Learning Response To Mechanical Stimulus Anterior/posterior Pattern Specification Response To Organic Cyclic Compound Negative Regulation Of Translation Dentate Gyrus Development Central Nervous System Neuron Development Neuron Projection Development Skeletal Muscle Cell Differentiation Response To Peptide Hormone Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Mitotic Cell Cycle Response To Electrical Stimulus Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Negative Regulation Of Neural Precursor Cell Proliferation
Pathways		RMTs methylate histone arginines TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Extra-nuclear estrogen signaling Estrogen-dependent gene expression	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs		S-adenosyl-L-homocysteine
Diseases
GWAS		Schizophrenia ( 29483656)	Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Red blood cell count ( 27863252) Red cell distribution width ( 27863252 28957414)
Interacting Genes		100 interacting genes: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C4orf17 CAPRIN1 CDC37 CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EIF4A1 EP300 ESR1 EWSR1 FAM83D FAM9A FBL FBXL17 FBXO7 FGF2 FLII FUS GPATCH2L GRHL3 GRIP1 H3C1 H4-16 H4C14 HABP4 HNF4A HNRNPA1 HNRNPK HNRNPR HNRNPU HNRNPUL1 HROB IDH3B IFNAR1 IGSF21 ILF3 IMPDH2 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MBP MECOM MED31 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 NTAQ1 OFCC1 PPARA PRMT8 QKI RBM15 RELA RNF187 RUNX1 S100A8 SAMD3 SHLD1 SIRT1 SPAG8 SPEG SPSB1 SPSB2 STAT1 STAT5A STUB1 SUPT5H SYNCRIP TBX6 TERF2 THRB TP53 TRIM48 UBAP2L UBE4B VHL VPS72 WDFY3 WDR33 YLPM1 YWHAG ZBTB14 ZMYM5 ZNF451	11 interacting genes: CNOT7 CNOT8 HOXB9 HOXC8 PICK1 PRKCA PRMT1 SKP2 SMAD1 SMAD9 SRA1
Entrez ID		3276	7832
HPRD ID		04257	03357
Ensembl ID		ENSG00000126457	ENSG00000159388
Uniprot IDs		Q99873	P78543
PDB IDs		6NT2	3DJU 3E9V
Enriched GO Terms of Interacting Partners?
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