HOXD4 and HIPK1

Number of citations of the paper that reports this interaction (PubMedID 9748262)
77

Data Source:
HPRD (two hybrid, in vitro)

		HOXD4	HIPK1
Description		homeobox D4	homeodomain interacting protein kinase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cell Junction	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Nuclear Speck
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Activating Transcription Factor Binding	Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Skeletal System Development Multicellular Organism Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis	Eye Development Protein Phosphorylation Smoothened Signaling Pathway Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Retina Layer Formation Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Neuron Differentiation Adherens Junction Assembly Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Angiogenesis Embryonic Camera-type Eye Morphogenesis Embryonic Retina Morphogenesis In Camera-type Eye Definitive Hemopoiesis Lens Induction In Camera-type Eye Iris Morphogenesis Endothelial Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Regulation of TP53 Activity through Phosphorylation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31015462) Male-pattern baldness ( 28196072) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Pelvic organ prolapse (moderate/severe) ( 26545240)	Alopecia areata ( 25608926) Breast cancer ( 23535729) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Heel bone mineral density ( 30598549)
Interacting Genes		19 interacting genes: ASB8 CNOT7 CREBBP DEDD EP300 ETV4 HIPK1 HNRNPAB HOXB13 MEIS1 PBX1 RNPS1 RXRG SNAI1 TIGD4 XRCC6 ZBTB32 ZMYND11 ZSCAN18	14 interacting genes: ATP13A2 CREBBP DAXX FHL3 GLUL HOXD4 NKX2-5 PARK7 PRPF40A RUNX1 SKIL SNIP1 TP53 UBE2I
Entrez ID		3233	204851
HPRD ID		00864	06418
Ensembl ID		ENSG00000170166	ENSG00000163349
Uniprot IDs		P09016	A0A024R0H9 B4DZ33 Q86Z02
PDB IDs
Enriched GO Terms of Interacting Partners?
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