EFEMP2 and FAM74A4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EFEMP2	FAM74A4
Description		EGF containing fibulin extracellular matrix protein 2	family with sequence similarity 74 member A4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Elastic Fiber Assembly
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758)
Interacting Genes		52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638	26 interacting genes: CCDC85B CCNDBP1 CEP44 EFEMP2 EMG1 HMBOX1 IKZF1 KRT31 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 LZTS2 MEOX2 MTUS2 NOTCH2NLA PDE4DIP PHC2 RPGRIP1 STX11 TCF4 TMCC2
Entrez ID		30008	401508
HPRD ID		05221	16982
Ensembl ID		ENSG00000172638	ENSG00000274583
Uniprot IDs		A0A024R5G1 O95967 Q9H3D5
PDB IDs		2KL7
Enriched GO Terms of Interacting Partners?
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