EFEMP2 and LCE3C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		EFEMP2	LCE3C
Description		EGF containing fibulin extracellular matrix protein 2	late cornified envelope 3C
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding	Protein Binding
	Biological Process	Elastic Fiber Assembly	Keratinization Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Molecules associated with elastic fibres Molecules associated with elastic fibres	Formation of the cornified envelope
Drugs
Diseases		Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Acne (severe) ( 24927181) Birth weight ( 31043758)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638	16 interacting genes: ADAMTSL4 EFEMP2 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-9 KRTAP9-4 NOTCH2NLA PCSK5 PLSCR1 RGS17 SPRY2
Entrez ID		30008	353144
HPRD ID		05221	17262
Ensembl ID		ENSG00000172638	ENSG00000244057
Uniprot IDs		A0A024R5G1 O95967 Q9H3D5	Q5T5A8
PDB IDs		2KL7
Enriched GO Terms of Interacting Partners?
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