UBQLN2 and HERC3

Number of citations of the paper that reports this interaction (PubMedID 18535780)
13

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		UBQLN2	HERC3
Description		ubiquilin 2	HECT and RLD domain containing E3 ubiquitin protein ligase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Autophagosome Cytosol Plasma Membrane Cytoplasmic Vesicle	Cytosol Cytoplasmic Vesicle
	Molecular Function	Protein Binding Polyubiquitin Modification-dependent Protein Binding	Ubiquitin-protein Transferase Activity
	Biological Process	Autophagosome Assembly Ubiquitin-dependent Protein Catabolic Process Regulation Of Macroautophagy Ubiquitin-dependent ERAD Pathway Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of ER-associated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Autophagosome Assembly	Protein Ubiquitination
Pathways		Cargo recognition for clathrin-mediated endocytosis	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: ADRM1 ATXN7 BTRC C1QA CD93 FBXO25 FUS HERC3 HERPUD1 HNRNPA3 HSPA13 MTNR1B PRPF40A PSMA2 PSMA5 PSMD4 RNF11 RPN1 SMURF1 UBC UBE3A UBQLN4	13 interacting genes: CCL22 CD33 HERC6 NME2 SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2
Entrez ID		29978	8916
HPRD ID		02224	16093
Ensembl ID		ENSG00000188021	ENSG00000138641
Uniprot IDs		Q9UHD9	B4DK41 H0Y8G9 Q15034
PDB IDs		1J8C 2NBV 6MUN
Enriched GO Terms of Interacting Partners?
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