GSN and LIMK2

Number of citations of the paper that reports this interaction (PubMedID 11171090)
48

Data Source:
HPRD (in vitro)

		GSN	LIMK2
Description		gelsolin	LIM domain kinase 2
Image
GO Annotations	Cellular Component	Ruffle Podosome Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Protein-containing Complex Secretory Granule Lumen Myelin Sheath Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cis-Golgi Network Mitotic Spindle
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Myosin II Binding Actin Filament Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Phagocytosis, Engulfment Aging Positive Regulation Of Gene Expression Oligodendrocyte Development Striated Muscle Atrophy Extracellular Matrix Disassembly Actin Filament Polymerization Regulation Of Cell Adhesion Protein Destabilization Tissue Regeneration Sequestering Of Actin Monomers Neutrophil Degranulation Cellular Protein Metabolic Process Actin Nucleation Response To Ethanol Negative Regulation Of Viral Entry Into Host Cell Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Response To Folic Acid Actin Filament Capping Cilium Assembly Cellular Response To Cadmium Ion Cellular Response To Interferon-gamma Regulation Of Podosome Assembly Actin Filament Reorganization Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Phosphorylation Spermatogenesis Phosphorylation Actin Cytoskeleton Organization Astral Microtubule Organization Head Development Cornea Development In Camera-type Eye
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Amyloid fiber formation	EPHB-mediated forward signaling Sema4D induced cell migration and growth-cone collapse RHO GTPases Activate ROCKs
Drugs		Zinc Latrunculin A Copper
Diseases		Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis
GWAS		Blood protein levels ( 30072576)	Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Paclitaxel-induced neuropathy ( 23776197) Sum eosinophil basophil counts ( 27863252) Type 2 diabetes nephropathy ( 21150874)
Interacting Genes		24 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN RAB14 STK39 TNIK TOM1L1 VASP VCL VDAC1	12 interacting genes: CDC42BPA CFL1 FBXO7 GSN H1-1 HIPK3 LIMK1 MBP NF1 PARD3 ROCK1 RPS6KA1
Entrez ID		2934	3985
HPRD ID		00674	03585
Ensembl ID		ENSG00000148180	ENSG00000182541
Uniprot IDs		A0A0A0MS51 A0A0A0MT01 A0A384MEF1 B7Z4U6 P06396	A0A024R1H6 A0A024R1M2 P53671
PDB IDs		1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5DD2 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6Q9R 6Q9Z 6QBF 6QW3	1X6A 4TPT 5NXD
Enriched GO Terms of Interacting Partners?
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