GPT and CDC7

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		GPT	CDC7
Description		glutamic--pyruvic transaminase	cell division cycle 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle
	Molecular Function	L-alanine:2-oxoglutarate Aminotransferase Activity Pyridoxal Phosphate Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Metal Ion Binding
	Biological Process	Cellular Amino Acid Biosynthetic Process Cellular Response To Insulin Stimulus Response To Starvation L-alanine Catabolic Process Positive Regulation Of Gluconeogenesis	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Positive Regulation Of Cell Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Peptidyl-serine Phosphorylation Cell Cycle Phase Transition Cell Division Negative Regulation Of G0 To G1 Transition
Pathways		Alanine metabolism	Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
Drugs		Pyridoxal Phosphate Glutamic Acid L-Alanine Phenelzine
Diseases
GWAS		Age at first birth ( 27798627) Alanine aminotransferase levels ( 30718733) Educational attainment ( 25201988) GLP-1 levels in response to oral glucose tolerance test (fasting) ( 29093273)	Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 25631615 31798171 28073927 21307088) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 31798171 25241763 28073927) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		2 interacting genes: CAPN1 CDC7	26 interacting genes: APP CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN CSDE1 DBF4 DBF4B DIAPH1 DTD1 GPT GRHPR MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC5 ORC6 TOB1
Entrez ID		2875	8317
HPRD ID		00689	10345
Ensembl ID		ENSG00000167701	ENSG00000097046
Uniprot IDs		P24298	A0A384MTU6 B2R6V2 O00311
PDB IDs			4F99 4F9A 4F9B 4F9C 5UWQ 5UWR
Enriched GO Terms of Interacting Partners?
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