GRK6 and EDNRA

Number of citations of the paper that reports this interaction (PubMedID 9211925)
42

Data Source:
HPRD (in vitro)

		GRK6	EDNRA
Description		G protein-coupled receptor kinase 6	endothelin receptor type A
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Cell Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway	Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Respiratory Gaseous Exchange Regulation Of Blood Pressure Cell Proliferation Regulation Of Glucose Transmembrane Transport Neural Crest Cell Development Artery Smooth Muscle Contraction Vasoconstriction Enteric Nervous System Development Head Development Endothelin Receptor Signaling Pathway
Pathways		G alpha (s) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Sitaxentan Ambrisentan Macitentan Sparsentan
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Coronary artery disease ( 29212778 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Ischemic stroke (large artery atherosclerosis) ( 29531354) Lead levels ( 26025379) Myocardial infarction ( 26343387) Obesity-related traits ( 23251661) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peripheral artery disease ( 26488411 31285632) Plasma clusterin levels ( 26545630) Plateletcrit ( 27863252) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Systolic blood pressure ( 27841878)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		2870	1909
HPRD ID		02925	00571
Ensembl ID		ENSG00000198055	ENSG00000151617
Uniprot IDs		B3KPS5 P43250	P25101
PDB IDs		2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?
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