GRK6 and PRSS23

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GRK6	PRSS23
Description		G protein-coupled receptor kinase 6	serine protease 23
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Endoplasmic Reticulum Lumen Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	Serine-type Endopeptidase Activity
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway	Proteolysis Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		G alpha (s) signalling events	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood urea nitrogen levels ( 31152163) Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29617998 29785010) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	25 interacting genes: ACTG1 APP B2M CHP1 EFNA3 FXR1 GATD1 GRK6 HSPA4 MAPK8IP2 NCAPD3 NIPBL NOC4L ODF2L PDPK1 PHF23 PPIA RACGAP1 RECQL4 RPL4P5 SHMT1 SLC25A6 TCF12 TMEM222 TRAPPC4
Entrez ID		2870	11098
HPRD ID		02925	07149
Ensembl ID		ENSG00000198055	ENSG00000150687
Uniprot IDs		B3KPS5 P43250	O95084
PDB IDs		2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?
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