GRK5 and BDKRB2

Number of citations of the paper that reports this interaction (PubMedID 11517230)
15

Data Source:
HPRD (in vitro, in vivo)

		GRK5	BDKRB2
Description		G protein-coupled receptor kinase 5	bradykinin receptor B2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Nuclear Speck Nuclear Membrane	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding Beta-adrenergic Receptor Kinase Activity	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Apoptotic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Negative Regulation Of Apoptotic Process Fat Cell Differentiation Protein Autophosphorylation Regulation Of Cell Cycle	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		G alpha (q) signalling events G alpha (s) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Anatibant Icatibant
Diseases
GWAS		Coronary artery aneurysm in Kawasaki disease ( 27171184) Early onset periodontitis x smoking status interaction ( 31537151) Height ( 28552196) Mean platelet volume ( 27863252) Methadone dose in opioid dependence ( 30060048) Obesity-related traits ( 23251661) Platelet distribution width ( 27863252) Risky sexual behaviors in alcohol dependence ( 28990359) Type 2 diabetes ( 22961080) Venous thromboembolism ( 31420334 31676865)	Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		19 interacting genes: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	12 interacting genes: ACE AGTR1 GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11
Entrez ID		2869	624
HPRD ID		02926	00213
Ensembl ID		ENSG00000198873	ENSG00000168398
Uniprot IDs		P34947	P30411
PDB IDs		4TNB 4TND
Enriched GO Terms of Interacting Partners?
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