BDKRB2 and GRK4

Number of citations of the paper that reports this interaction (PubMedID 11517230)
15

Data Source:
HPRD (in vivo, in vitro)

		BDKRB2	GRK4
Description		bradykinin receptor B2	G protein-coupled receptor kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Cell Endosome Plasma Membrane Integral Component Of Plasma Membrane	Cytosol Cell Cortex Dendrite Neuronal Cell Body Photoreceptor Disc Membrane
	Molecular Function	Protease Binding Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity	G Protein-coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity
	Biological Process	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator	G Protein-coupled Receptor Internalization Protein Phosphorylation Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Receptor Internalization
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		Anatibant Icatibant
Diseases
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)	Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		12 interacting genes: ACE AGTR1 GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11	6 interacting genes: ADRB2 BDKRB2 CALM1 FSHR IKBKG NEDD4
Entrez ID		624	2868
HPRD ID		00213	00656
Ensembl ID		ENSG00000168398	ENSG00000125388
Uniprot IDs		P30411	P32298
PDB IDs			4YHJ
Enriched GO Terms of Interacting Partners?
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