GLUD1 and LSM1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)

		GLUD1	LSM1
Description		glutamate dehydrogenase 1	LSM1 homolog, mRNA degradation associated
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Matrix	P-body Nucleus Cytoplasm Cytosol Axon Dendrite Neuronal Cell Body Messenger Ribonucleoprotein Complex Lsm1-7-Pat1 Complex
	Molecular Function	Glutamate Dehydrogenase (NAD+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Protein Binding ATP Binding GTP Binding Identical Protein Binding ADP Binding NAD+ Binding Leucine Binding	RNA Cap Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding
	Biological Process	Glutamate Biosynthetic Process Glutamate Catabolic Process Glutamine Metabolic Process Cellular Amino Acid Biosynthetic Process Substantia Nigra Development Positive Regulation Of Insulin Secretion Oxidation-reduction Process Tricarboxylic Acid Metabolic Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Metabolic Process Stem Cell Population Maintenance Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process
Pathways		Transcriptional activation of mitochondrial biogenesis Glutamate and glutamine metabolism	mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease
Drugs		Glutamic Acid NADH Hexachlorophene Guanosine-5'-Triphosphate Aluminum chloride
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 22037555 29483656)
Interacting Genes		12 interacting genes: ASGR2 CRP DYNLL1 GOT2 HPX HSD17B10 LSM1 NR4A1 ORM1 SEC62 STAT5A VTN	27 interacting genes: CLIC1 EXOSC6 EXOSC8 GLUD1 GOLGA7 GRHPR HSP90AA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TFCP2 TMEM214 UPF2 UXT VPS11
Entrez ID		2746	27257
HPRD ID		11748	06281
Ensembl ID		ENSG00000148672	ENSG00000175324
Uniprot IDs		E9KL48 P00367	A0A0S2Z590 O15116
PDB IDs		1L1F 1NR1 6DQG
Enriched GO Terms of Interacting Partners?
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