LSM1 and NDUFAF3

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		LSM1	NDUFAF3
Description		LSM1 homolog, mRNA degradation associated	NADH:ubiquinone oxidoreductase complex assembly factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Axon Dendrite Neuronal Cell Body Messenger Ribonucleoprotein Complex Lsm1-7-Pat1 Complex	Nucleus Mitochondrial Inner Membrane
	Molecular Function	RNA Cap Binding RNA Binding MRNA Binding Protein Binding Pre-mRNA Binding	Protein Binding
	Biological Process	Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA RNA Splicing, Via Transesterification Reactions MRNA Processing RNA Splicing RNA Metabolic Process Stem Cell Population Maintenance Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Negative Regulation Of Neuron Differentiation Histone MRNA Catabolic Process	Mitochondrial Respiratory Chain Complex I Assembly
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease	Complex I biogenesis
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 22037555 29483656)	Blood protein levels ( 28240269) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Ulcerative colitis ( 28067908)
Interacting Genes		27 interacting genes: CLIC1 EXOSC6 EXOSC8 GLUD1 GOLGA7 GRHPR HSP90AA1 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MPDU1 N4BP1 NARS1 NDUFAF3 PSMB5 PSMB8 PTPRC RRP1B SMN1 TFCP2 TMEM214 UPF2 UXT VPS11	8 interacting genes: GEM KRTAP10-3 LSM1 NDUFAF4 RBCK1 REL SCAP SNRPA
Entrez ID		27257	25915
HPRD ID		06281	16809
Ensembl ID		ENSG00000175324	ENSG00000178057
Uniprot IDs		A0A0S2Z590 O15116	A4FU71 Q9BU61 Q9Y3Z0
PDB IDs
Enriched GO Terms of Interacting Partners?
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