GHRHR and GHRH

Number of citations of the paper that reports this interaction (PubMedID 1333056)
30

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		GHRHR	GHRH
Description		growth hormone releasing hormone receptor	growth hormone releasing hormone
Image
GO Annotations	Cellular Component	Cell Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Matrix Secretory Granule Sarcolemma	Extracellular Region Extracellular Space Neuron Projection Terminal Bouton Perikaryon
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding	Neuropeptide Hormone Activity Growth Hormone-releasing Hormone Activity Growth Hormone-releasing Hormone Receptor Binding Peptide Hormone Receptor Binding
	Biological Process	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Lactation Positive Regulation Of Cell Proliferation Determination Of Adult Lifespan CAMP-mediated Signaling Water Homeostasis Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Maturation Multicellular Organismal Reproductive Process Regulation Of Protein Metabolic Process Response To Glucocorticoid Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development Cellular Response To Glucose Stimulus	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Adenohypophysis Development Growth Hormone Secretion Response To Food Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Growth Hormone Secretion
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs		Sermorelin Tesamorelin
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Height ( 31562340)
Interacting Genes		3 interacting genes: GHRH GHRL MLNR	1 interacting genes: GHRHR
Entrez ID		2692	2691
HPRD ID		00748	11752
Ensembl ID		ENSG00000106128	ENSG00000118702
Uniprot IDs		A0A090N8Y6 Q02643	P01286
PDB IDs		2XDG	5BQM
Enriched GO Terms of Interacting Partners?
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