GHRH and GHRHR

Number of citations of the paper that reports this interaction (PubMedID 1333056)
30

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		GHRH	GHRHR
Description		growth hormone releasing hormone	growth hormone releasing hormone receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Neuron Projection Terminal Bouton Perikaryon	Cell Nuclear Inner Membrane Nuclear Outer Membrane Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane Nuclear Matrix Secretory Granule Sarcolemma
	Molecular Function	Neuropeptide Hormone Activity Growth Hormone-releasing Hormone Activity Growth Hormone-releasing Hormone Receptor Binding Peptide Hormone Receptor Binding	G Protein-coupled Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Growth Hormone-releasing Hormone Receptor Activity Peptide Hormone Binding Growth Factor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Positive Regulation Of Cell Proliferation Adenohypophysis Development Growth Hormone Secretion Response To Food Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Circadian Sleep/wake Cycle, REM Sleep Positive Regulation Of Growth Hormone Secretion	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Lactation Positive Regulation Of Cell Proliferation Determination Of Adult Lifespan CAMP-mediated Signaling Water Homeostasis Response To Insulin Cellular Response To Insulin Stimulus Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Response To Estrogen Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Maturation Multicellular Organismal Reproductive Process Regulation Of Protein Metabolic Process Response To Glucocorticoid Positive Regulation Of Growth Hormone Secretion Somatotropin Secreting Cell Development Cellular Response To Glucose Stimulus
Pathways		G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production	G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production
Drugs			Sermorelin Tesamorelin
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Height ( 31562340)
Interacting Genes		1 interacting genes: GHRHR	3 interacting genes: GHRH GHRL MLNR
Entrez ID		2691	2692
HPRD ID		11752	00748
Ensembl ID		ENSG00000118702	ENSG00000106128
Uniprot IDs		P01286	A0A090N8Y6 Q02643
PDB IDs		5BQM	2XDG
Enriched GO Terms of Interacting Partners?
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