BSCL2 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		BSCL2	PLEKHF2
Description		BSCL2 lipid droplet biogenesis associated, seipin	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Integral Component Of Endoplasmic Reticulum Membrane	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane
	Molecular Function	Molecular_function Protein Binding	Protein Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Lipid Catabolic Process Lipid Storage Lipid Droplet Organization Fat Cell Differentiation Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Cold-induced Thermogenesis	Protein Transport
Pathways
Drugs
Diseases		Hereditary spastic paraplegia (SPG) Congenital generalized lipodystrophy (CGL) Distal hereditary motor neuropathies (dHMN)
GWAS		Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Radiation response ( 20923822)
Interacting Genes		8 interacting genes: CPEB2 NSG1 PLEKHF2 PLIN1 SMIM3 SMLR1 TMEM19 USE1	71 interacting genes: ACY3 AIDA AIMP2 APP APPL1 ARL14EP BEND7 BLOC1S6 BSCL2 CAVIN2 CCDC172 CCDC85B CEP44 CGGBP1 CHIC2 DPPA4 DRAP1 DTX2 DUT ESRP1 FBXO28 FHL3 FOXA1 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HEY1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NKG7 NONO NPM2 PDP1 PEX2 PRDM14 PRKAR1A PRPSAP1 RAB39A RABAC1 RADX RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SPEF1 TBX3 TCN2 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z USF1 ZNF250 ZNF263 ZNF398
Entrez ID		26580	79666
HPRD ID		05858	15147
Ensembl ID		ENSG00000168000	ENSG00000175895
Uniprot IDs		A0A024R540 A0A024R549 Q96G97	Q9H8W4
PDB IDs		6DS5
Enriched GO Terms of Interacting Partners?
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