GCSH and NMI

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		GCSH	NMI
Description		glycine cleavage system protein H	N-myc and STAT interactor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Aminomethyltransferase Activity Protein Binding	Transcription Coregulator Activity Protein Binding Identical Protein Binding
	Biological Process	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System	Transcription By RNA Polymerase II Inflammatory Response JAK-STAT Cascade Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Innate Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Nucleic Acid-templated Transcription
Pathways		Glyoxylate metabolism and glycine degradation Glycine degradation
Drugs		Glycine 6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases		Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 28240269)
Interacting Genes		4 interacting genes: ING5 NMI SFI1 ZBTB16	54 interacting genes: BRCA1 BRMS1 C1orf216 C9orf72 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EXOSC5 GCSH GOLGA8EP HDDC3 HGS HHLA3 HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 TRAF5 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I
Entrez ID		2653	9111
HPRD ID		01998	04632
Ensembl ID		ENSG00000140905	ENSG00000123609
Uniprot IDs		P23434	Q13287
PDB IDs
Enriched GO Terms of Interacting Partners?
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