NMI and C9orf72

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NMI	C9orf72
Description		N-myc and STAT interactor	C9orf72-SMCR8 complex subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	P-body Extracellular Space Nucleus Cytoplasm Lysosome Endosome Autophagosome Cytoplasmic Stress Granule Dendrite Nuclear Membrane Guanyl-nucleotide Exchange Factor Complex Perikaryon Axonal Growth Cone Main Axon Atg1/ULK1 Kinase Complex
	Molecular Function	Transcription Coregulator Activity Protein Binding Identical Protein Binding	Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Rab GTPase Binding
	Biological Process	Transcription By RNA Polymerase II Inflammatory Response JAK-STAT Cascade Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Innate Immune Response Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein K48-linked Ubiquitination Regulation Of Nucleic Acid-templated Transcription	Negative Regulation Of Protein Phosphorylation Endocytosis Autophagy Regulation Of Autophagy Positive Regulation Of Macroautophagy Stress Granule Assembly Axon Extension Regulation Of Actin Filament Organization Late Endosome To Lysosome Transport Regulation Of TORC1 Signaling Negative Regulation Of GTP Binding Regulation Of Autophagosome Assembly
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 28240269)	Amyotrophic lateral sclerosis ( 30976013 25442119 29566793 22959728 27455348 19734901 20801718 24931836) Amyotrophic lateral sclerosis (sporadic) ( 28931804) Delirium ( 29631748) Metabolite levels ( 23823483) PCA3 expression level ( 23555189)
Interacting Genes		54 interacting genes: BRCA1 BRMS1 C1orf216 C9orf72 CDKN2A CDKN2D CNKSR3 CNOT7 COPS7B CYP2E1 EMILIN1 EXOSC5 GCSH GOLGA8EP HDDC3 HGS HHLA3 HOXC9 HSPA8 HSPH1 IFI35 KDM1A LCA5L LSM4 MAD2L1BP MCPH1 MORF4L1 MTMR6 MTMR9 MYC MYCN NECAP2 POMZP3 PSMA1 RYBP SCEL SFR1 SH3GLB2 SINHCAF SNAPC5 SOX10 STAT1 STAT3 STAT4 STAT5A STAT5B STAT6 TRAF5 TRIP12 TUBA3C TUBA3E TXLNA TXLNB UBE2I	7 interacting genes: APP CRX EIF2B2 NMI REL SMN1 SRPK1
Entrez ID		9111	203228
HPRD ID		04632	12975
Ensembl ID		ENSG00000123609	ENSG00000147894
Uniprot IDs		Q13287	Q96LT7
PDB IDs
Enriched GO Terms of Interacting Partners?
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